![](https://www.mskcc.org/sites/default/files/node/1602/main_image_large/national-cancer-institute_1920x384.jpg)
Molecular Pharmacology Program
The Neal Rosen Lab
Research
![Pictured: Neal Rosen](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1602/person/rosen_180503_03_1200x800.jpg?h=10d202d3)
The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the dysregulation of growth and inhibition of apoptosis that characterize advanced human cancer. Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies.
Research Projects
![Neal Rosen Lab Group](https://www.mskcc.org/sites/default/files/node/1602/3x2/rosen-lab-group180425_01_1200x800.jpg)
Featured News
![Piro Lito, Bob Li, and Neal Rosen in the lab](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/209119/main_image/msk_200917_036-1200x800.jpg)
![Scott Lowe and Neal Rosen](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/128422/3x2/rose_lowe_3x2.jpg)
![Colored x-ray of lung cancer](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/118888/3x2/xray-lung-cancer.jpg)
Publications Highlights
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nat Chem Biol. 2021 Oct;17(10):1065-1074. doi: 10.1038/s41589-021-00813-7. Epub 2021 Jun 24. Erratum in: Nat Chem Biol. 2021 Jun 29;: Erratum in: Nat Chem Biol. 2021 Nov;17(11):1209. PMID: 34168367.
Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N. Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Mol Cell. 2021 Feb 18;81(4):708-723.e5. doi: 10.1016/j.molcel.2021.01.033. PMID: 33606974; PMCID: PMC8384339.
Yao, Z., Gao, Y., Su, W., Yaeger, R., Tao, J., Na, N., Zhang, Y., Zhang, C., Rymar, A., Tao, A., Timaul, N. M., Mcgriskin, R., Outmezguine, N. A., Zhao, H., Chang, Q., Qeriqi, B., Barbacid, M., de Stanchina, E., Hyman, D. M., Bollag, G., … Rosen, N. (2019). RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling. Nature medicine, 25(2), 284–291. https://doi.org/10.1038/s41591-018-0274-5
Gao, Y., Chang, M. T., McKay, D., Na, N., Zhou, B., Yaeger, R., Torres, N. M., Muniz, K., Drosten, M., Barbacid, M., Caponigro, G., Stuart, D., Moebitz, H., Solit, D. B., Abdel-Wahab, O., Taylor, B. S., Yao, Z., & Rosen, N. (2018). Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties. Cancer discovery, 8(5), 648–661. https://doi.org/10.1158/2159-8290.CD-17-1452
Yaeger, R., Chatila, W. K., Lipsyc, M. D., Hechtman, J. F., Cercek, A., Sanchez-Vega, F., Jayakumaran, G., Middha, S., Zehir, A., Donoghue, M., You, D., Viale, A., Kemeny, N., Segal, N. H., Stadler, Z. K., Varghese, A. M., Kundra, R., Gao, J., Syed, A., Hyman, D. M., … Schultz, N. (2018). Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. Cancer cell, 33(1), 125–136.e3. https://doi.org/10.1016/j.ccell.2017.12.004
People
![Pictured: Neal Rosen](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1602/person/rosen_180503_03_1200x800.jpg?h=10d202d3)
Neal Rosen, MD, PhD
- Pharmacologist Neal Rosen focuses on understanding biochemical mechanisms underlying phenotypes caused by tyrosine kinase activation in epithelial tumors and developing new therapeutic strategies.
- MD, PhD, Albert Einstein College of Medicine
- [email protected]
- Email Address
- 646-888-2075
- Office Phone
- View physician profile
- Physician profile
Members
![Jacob A. Boyer](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/34648/3x2/boyer-jacob_180425_05_1200x800.jpg?h=10d202d3)
- BS, Pennsylvania State University
![Jacob A. Boyer](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/34648/3x2/boyer-jacob_180425_05_1200x800.jpg?h=10d202d3)
Ludwig Princeton Scholar in Cancer Metabolism at Princeton University, Princeton, NJ
Instructor
![Sunyana Gadal](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/19635/3x2/gadal-sunyana_180425_07_1200x800.jpg?h=10d202d3)
Research Fellow
Research Technician
Research Fellow
![Sandra Misale](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156814/3x2/misale-sandra180425_06_1200x800.jpg?h=10d202d3)
Research Associate
![Radha Mukherjee](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/39141/3x2/mukherjee-radha_180425_07_1200x800.jpg?h=10d202d3)
Research Fellow
Research Assistant
Research Fellow
![Hilla Solomon](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/162883/3x2/solomon-hilla_190213_03_1200x800.jpg?h=10d202d3)
Research Associate
![N. Merna Timaul](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/19644/3x2/neilawattie-torres_180425_08_1200x800.jpg)
Lab Manager
![Rory Mcgriskin](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156805/3x2/mcgriskin-rory_180425_03_1200x800.jpg?h=10d202d3)
![Claire Thant](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156808/3x2/thant-_claire_190213_05_1200x800-1.jpg?h=10d202d3)
![Jianing Xu](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156811/3x2/xu-jianing_180425_03_1200x800.jpg?h=10d202d3)
Lab Alumni
Former Research Technician
Assistant Member, Human Oncology and Pathogenesis Program; Department of Medicine, Memorial Sloan Kettering Cancer Center
Assistant Professor, Mount Sinai
Research Fellow
Faculty, University of Kentucky
![Piro Lito](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/19638/image/lito.jpg?h=10d202d3)
Enid A. Haupt Chair in Therapeutic Research
Director, Developmental Therapeutics; Associate Professor of Medicine; Cell and Developmental Biology, Memorial Sloan Kettering Cancer Center
Former Graduate Student
Assistant Attending, Department of Pediatrics
Research Fellow
Research Technician
Former Research Technician
Former Graduate Student
Research Fellow
Former Research Fellow
Research Technician
Former Research Technician
Research Fellow
![Yijun Gao](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/39139/3x2/gao_0.jpg?h=c9f93661)
Research Associate
Research Technician
![Hidenori Kitai](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/171802/3x2/kitai-_hidenori_190213_03_1200x800-1.jpg?h=10d202d3)
Visiting Investigator
![Rory Mcgriskin](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156805/3x2/mcgriskin-rory_180425_03_1200x800.jpg?h=10d202d3)
Medical Lab Assistant
Lab Technician
![Na Na](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/125158/3x2/na-na_180425_04_1200x800.jpg?h=10d202d3)
Research Technician
![Virginia Ojeda Seijas](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/125152/3x2/seijas-virginia_180425_05_1200x800.jpg?h=10d202d3)
Research Fellow
Research Technician
![Vanessa Rodrik-Outmezguine](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1620/3x2/rodrik-outmezguine.jpg)
Senior Scientist
![Wenjing Su](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156820/3x2/wenjing-su_180425_06_1200x800.jpg?h=10d202d3)
Research Associate
![Claire Thant](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156808/3x2/thant-_claire_190213_05_1200x800-1.jpg?h=10d202d3)
Senior Research Technician
Research Technician
![Adele Whaley](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/142930/3x2/whaley-_adele_190213_03_1200x800-1.jpg?h=10d202d3)
![Jianing Xu](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/156811/3x2/xu-jianing_180425_03_1200x800.jpg?h=10d202d3)
Research Associate
![Rona Yaeger](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1622/3x2/yeager.jpg?h=10d202d3)
Assistant Attending Physician, Department of Medicine
![Zhan Yao](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/19648/3x2/zhan-yao_180425_05_1200x800.jpg?h=10d202d3)
Assistant Lab member
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Postdoctoral Positions
Get in Touch
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Lab Head Email
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Office Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Neal Rosen discloses the following relationships and financial interests:
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BeiGene, Ltd.
Equity; Professional Services and Activities -
Chugai Pharmaceuticals
Professional Services and Activities -
eFFECTOR Therapeutics
Equity -
Fortress Biotech Inc
Equity -
Ikena Oncology
Professional Services and Activities -
Jubilant Therapeutics Inc.
Professional Services and Activities (Uncompensated)
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Kura Oncology
Equity -
Lutris Pharma Ltd.
Intellectual Property Rights -
MapKure LLC
Equity; Professional Services and Activities -
Revolution Medicines
Professional Services and Activities (Uncompensated) -
Ribon Therapeutics
Professional Services and Activities -
Zai Lab
Equity; Professional Services and Activities
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].