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Chemical Biology Program
The Derek Tan Lab
Research
![Derek Tan, research lab head](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1828/image/tan-derek.jpg?h=10d202d3)
The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design as complementary approaches to ligand discovery. Our work in both of these areas is influenced at multiple levels by insights from natural products. At the core of these efforts is the development of new chemical methodologies to provide flexible, efficient, systematic access to these structures. We leverage multidisciplinary collaborations with biologists to evaluate these molecules to probe key biological processes and to explore new therapeutic opportunities in cancer and infectious diseases. Our group is strongly committed to promoting diversity and inclusion at all levels and welcomes scientists from all backgrounds!
Research Projects
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Featured News
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Publications Highlights
Design and semisynthesis of biselectrophile-functionalized ubiquitin probes to investigate transthioesterification reactions.
Avelyn Mae V. Delos Reyes, Michaelyn C. Lux, Zachary S. Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D. Lima*, and Derek S. Tan*, Org. Lett. 2024, 26, 4594-4599.
[ Abstract | PubMed | PMC ]
Direct conversion of amino acids to oxetanol bioisosteres via photoredox catalysis.
Delos Reyes, A. M. V.; Nieves Escobar, C. S.; Muñoz, A.; Huffman, M. I.; Tan, D. S.* Chem Sci. 2023, 14, 10524-10531.
[ Abstract | PubMed | PMC ]
Development of a p-hydroxybenzyl-alcohol-linked glutamate prodrug for activation by Pseudomonas carboxypeptidase G2.
Lee, J. P.; Corless, B. C.; Gardner, T. J.; Scheinberg, D. A.; Tan, D. S.* Org. Lett. 2023, 6295–6299.
[ Abstract | PubMed | PMC ]
People
![Derek Tan, research lab head](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1828/image/tan-derek.jpg?h=10d202d3)
Derek Tan, PhD
Chair, Chemical Biology Program, SKI; Tri-Institutional Professor; Eugene W. Kettering Chair
- Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.
- BS, Stanford University
- PhD, Harvard University
- [email protected]
- Email Address
- Download CV
- PDF File
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Summer Intern
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Summer Intern
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Summer Intern
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Summer Intern
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Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/3746/image/347440.jpg)
Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/114523/3x2/boudreau-1200-x-800.jpg?h=10d202d3)
Summer Intern
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Summer Intern
![Mikaela DiBello](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158419/3x2/mikaela-1200x800.jpg?h=10d202d3)
Summer Intern
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Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/126127/3x2/derekg-1200x800.jpg?h=10d202d3)
Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17622/image/christopherg.jpg)
Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/34252/image/eun-bin.jpg?h=6c83441f)
Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/228100/main_image/huffman-maya.jpg?h=10d202d3)
Summer Intern
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Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/6193/image/leon.jpg)
Summer Intern
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Summer Intern
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Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/114988/3x2/ramdular_1200x800.jpg?h=10d202d3)
Summer Intern
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/178231/3x2/allison-1200x800.jpg?h=10d202d3)
Summer Intern
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Summer Intern
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Administrative Assistant
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2777/image/252850.jpg?h=52605a11)
Administrative Assistant
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2302/image/67683.jpg?h=52605a11)
Administrative Assistant
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2758/image/250359.jpg?h=52605a11)
Pharmacology Rotation Student
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Pharmacology Rotation Student
TPCB Rotation Student
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TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5763/image/508273.jpg?h=52605a11)
MD-PhD Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/20088/image/chanhee.jpg)
MD-PhD Rotation Student (2013)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/289351/main_image/image001.png?h=449fb67a)
TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2345/image/placeholder.jpg)
TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/3745/image/347434.jpg?h=52605a11)
TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17927/image/paolo.jpg)
TPCB Rotation Student
TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2225/image/50962.jpg)
TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/289346/main_image/ag_msk_photo.png?h=309e12e8)
TPCB Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2663/image/226869.jpg?h=52605a11)
TPCB Rotation Student
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TPCB Rotation Student
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TPCB Rotation Student
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TPCB Rotation Student
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TPCB Rotation Student
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GSK Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4519/image/428753.jpg)
Pharm Rotation Student
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TPCB Rotation Student
![Pengju Nie, BS](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/38875/image/placeholder-2014.jpg?h=10d202d3)
Pharmacology Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/3743/image/347422.jpg)
TPCB Rotation Student
Pharmacology Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2350/image/80735.jpg)
Pharmacology Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/295346/main_image/img_8158.jpg?h=c63cfea8)
Pharmacology Rotation Student
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TPCB Rotation Student
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Pharmacology Rotation Student
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TPCB Rotation Student
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TPCB Rotation Student
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TPCB Rotation Student (2013)
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TPCB Rotation Student
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TPCB Rotation Student
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GSK Rotation Student
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TPCB Rotation Student
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Pharmacology Rotation Student
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TPCB Rotation Student
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TPCB Rotation Student
![Svena Verma](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158437/3x2/svena-1200x800_0.jpg)
Pharmacology Rotation Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2664/image/226875.jpg)
MD-PhD Rotation Student
![Evelyn Warner, BA](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/38876/image/placeholder-2014.jpg?h=10d202d3)
TPCB Rotation Student
![Isa Watson](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4332/image/watson-isa.jpg?h=10d202d3)
Pharmacology Rotation Student
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TPCB Rotation Student
Lab Affiliations
Achievements
- Development of salicyl-AMS, a novel antibacterial agent to treat tuberculosis and other infections
- Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2010)
- Dean's Award for Excellence in Teaching and Mentoring, Weill Cornell Graduate School of Medical Sciences (2013)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Derek Tan discloses the following relationships and financial interests:
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Adjuvance Technologies
Intellectual Property Rights -
Aflac Inc.
Equity -
Amgen
Equity -
CoImmune, Inc.
Equity; Intellectual Property Rights; Professional Services and Activities (Uncompensated) -
CVS Caremark Corp
Equity -
Institute for Research in Biomedicine Barcelona
Professional Services and Activities -
Medtronic
Equity
-
Merck & Co Inc.
Equity -
Moderna, Inc.
Equity -
Regeneron Pharmaceuticals, Inc.
Equity -
Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM)
Professional Services and Activities -
Solventum Corporation
Equity -
Tri-Institutional Therapeutics Discovery Institute
Fiduciary Role / Position -
UnitedHealth Group
Equity
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].