Memorial Hospital Research Laboratories

The Liang Deng Lab

Research

Liang Deng, MD, PhD
Liang Deng, MD, PhD

Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma.

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Research Projects

Figure 1
The Liang Deng Lab

Featured News

Pictured: Liang Deng
At Work: Physician-Scientist Liang Deng
Physician-scientist Liang Deng cares for patients with melanoma and other skin cancers, and also conducts innovative research on poxviruses.
Imagination to Discovery
Three emerging investigators are tackling the mysteries of biology and cancer at Memorial Sloan Kettering.

Publications Highlights

Yang, N., Wang, Y., Dai, P., Li, T., Zierhut, C., Tan, A., Zhang, Z., Pan, H., Li, Z., Ordureau, A., Xiang, J.Z., Hendrickson, R.C., Funabiki H., Chen, Z., Deng, L. (2023) Vaccinia E5 is a major inhibitor of the DNA sensor cGAS. Nat Commun, 14(1):2898. doi: 10.1038/s41467-023-38514-5 (PMC10201048).

Yang, N., #, Wang, Y.,#, Liu, S., Tariq, S.B., Luna, J. M., Mazo G., Tan, A., Zhang, T., Wang, J., Yan, W.,  Choi, J., Rossi, A., Xiang, J.Z., Rice, C. M., Merghoub, T., Wolchok, J. D., and Deng, L. (2023) OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. Journal Experimental Medicine 220(8):e20221166. Epub 2023 May 5. PMID: 37145142.

Gu, L., Lin, E., Liu, S., Yang, N., Kurtansky, N., Neumann, N., Stoll, J., Lezcano, C., Pulitzer, M., Noor, S., Markova, A., Rossi, A., Dickson, M., and Deng L.  (2023) Efficacy of Immunotherapy with Combination of Cryotherapy and Topical Imiquimod for Treatment of Kaposi Sarcoma. Journal of Medical Virology, 95(1):e28396. PMID: 36504005.

Yang, N., Garcia, A., Meyer, Tuschl T., Merghoub, T., Wolchok, J.D., and L. Deng (2022) Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant. npj Vaccines (2022) 7(1):120. PMID: 36261460. https://doi.org/10.1038/s41541-022-00542-5.

Yang, N., Luna J.M., Dai, P., Wang, Y., Rice, C.M., and L. Deng. (2022). Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection. Nature Communications 13(1):1671. PMID: 35351885. PMCID: PMC896475.

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People

Liang Deng, MD, PhD

Liang Deng, MD, PhD

  • Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
[email protected]
Email Address
646-888-6011
Office Phone
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Physician profile

Members

Liang Deng, MD, PhD
Liang Deng
Lab Head
Shanza Baeer-Tariq
Research Technician
Bharath Salla
Research Technician
Yueqi Wang
Research Technician
Ning Yang
Ning Yang
Senior Research Scientist
Peihong Dai
Peihong Dai
Research Assistant
Weiyi Wang, PhD
Weiyi Wang
Senior Research Scientist
Biao Huang
Visiting Scholar
Shuaitong Liu
Shuaitong Liu
Research Technician
Gregory Mazo
Gregory Mazo
Research Fellow
Zhaoyang Niu
Research Fellow
Cristian Serna-Tamayo
Medical Student Research Fellow
Yi Wang
Yi Wang
Research Assistant

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

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Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Liang Deng discloses the following relationships and financial interests:

  • Immunogenesis, Inc.
    Intellectual Property Rights
  • Imvaq Therapeutics
    Equity; Intellectual Property Rights; Professional Services and Activities (Uncompensated)

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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