Structural Biology Program
The Alexandros Pertsinidis Lab
Research
![Alexandros Pertsinidis, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5809/image/pertsinidis-alexandros.jpg?h=10d202d3)
Our mission is the development of a “new” generation of optical imaging technologies to enable advances in two hitherto difficult-to-investigate areas: the real-time analysis of macromolecular interactions and motions at the nanometer scale in vivo and the three-dimensional architecture of complex molecular machines and of subcellular ultrastructure, in situ. We are also refining and applying ultrahigh-resolution spectroscopy techniques to dissect multistep complex biochemical processes using in vitro reconstituted single-molecule assays.
Research Projects
Featured News
![Regulatory proteins (gold balls) bind to enhancer regions (light blue) and promoter regions (pink) of DNA to form clusters that enable transcription (purple).](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/209212/main_image/27276_pertsinidis.4_1200x800.jpg)
![Molecular image with target symbol](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/178573/main_image/1130038240501682.lktrrh5nudtn62ulkrid_height640.png)
Publications Highlights
People
![Alexandros Pertsinidis, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5809/image/pertsinidis-alexandros.jpg?h=10d202d3)
Alexandros Pertsinidis, PhD
Professor, Biochemistry and Structural Biology Program
- The Pertsinidis laboratory uses single-molecule approaches to understand gene transcription and the function of complex macromolecular machines inside live cells.
- PhD, Brown University
- [email protected]
- Email Address
- 212-639-5258
- Office Phone
Members
![Alexandros Pertsinidis, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5913/image/pertsinidis-alexandros.jpg?h=10d202d3)
![Lingling Cheng](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/210166/main_image/cheng-lingling-230606-03_rt_1200x800.jpg)
![Alexandros Pertsinidis, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5913/image/pertsinidis-alexandros.jpg?h=10d202d3)
Professor, Biochemistry and Structural Biology Program
![Lingling Cheng](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/210166/main_image/cheng-lingling-230606-03_rt_1200x800.jpg)
Research Scholar
Research Fellow
Research Scholar
![Jieru Li](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/157366/3x2/li-jieru_180427_12_1200x800.jpg?h=10d202d3)
Research Fellow
Research Scholar
Research Associate
![Bin Cao](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/157369/3x2/cao-bin_180427_05_1200x800.jpg?h=10d202d3)
Lab Alumni
![Kathleen Maria Mills, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/6180/image/mills-kathleen.jpg)
Research Fellow
![Guanshi Wang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17549/image/wang-guanshi.jpg)
Graduate Student
![Pai-tseng Kuo, MD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17550/image/kuo-pai-tseng.jpg)
Graduate Student
![Jesse Hauver](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17551/image/hauver-jesse.jpg)
Graduate Student
![Justin Yeh](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17548/image/yeh-justin.jpg)
Research Technician
![Osaze Udeagbala](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17552/image/udeagbala-osaze.jpg)
Undergraduate Student Intern
![Madelyn Myers](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17554/image/myers-madelyn.jpg)
Masters Student Intern
![Tianyi (Terence) Cai](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/17553/image/cai-tianyi.jpg)
Undergraduate Student Intern
![Bin Cao](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/157369/3x2/cao-bin_180427_05_1200x800.jpg?h=10d202d3)
Research Fellow
![Kadeem P. Ho Sang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/35353/main_image/ho-sang-kadeem_210830_010-1200x800.jpg?h=10d202d3)
Administrative Research Assistant
Research Technician
Research Associate
Lab Affiliations
Achievements
- Director’s New Innovator Award, National Institutes of Health (2012)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
Get in Touch
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Lab Head Email
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Office Phone
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Office Fax
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Alexandros Pertsinidis discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].