Structural Biology Program
The Stephen Long Lab
Research
![Stephen B. Long, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/3845/person/long_190205_13_1200x800.jpg?h=10d202d3)
Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development, and they are potential targets for diseases including immune disorders and cancer. Our discoveries lead to new understandings of the fundamental mechanisms of the ion channels and enzymes. These understandings also guide our efforts to develop and evaluate small molecule and biologic modulators for therapeutic potential for cancer and other diseases.
![Human two-pore domain potassium channel](https://www.mskcc.org/sites/default/files/node/3845/images/overall-ribbons.jpg)
Human two-pore domain potassium channel
![Voltage-dependent potassium channel and Two-pore domain potassium channel](https://www.mskcc.org/sites/default/files/node/3845/images/potassium-channel.jpg)
![Voltage-dependent potassium channel and Two-pore domain potassium channel](https://www.mskcc.org/sites/default/files/node/3845/images/potassium-channel-2.jpg)
![X-ray structures of eukaryotic calcium, potassium, and chloride channels determined in the lab](https://www.mskcc.org/sites/default/files/node/3845/images/structures-website_0.jpg)
![Pictured: Stephen B Long Lab](https://www.mskcc.org/sites/default/files/node/3845/images/long-lab-photo_210630_001.jpg)
Long Lab circa 2021
Featured News
![A scientist holding a tube in a lab](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/238147/main_image/210210-km-karuna_ganesh-28_rt-12x8.jpeg)
![A gray blob marked RAS linked to colorful rods marked ICMT](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/151024/3x2/icmt_ternary_web_ver1-1200x800.jpg)
![Pictured: Stephen Long & Alexandria Miller](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/25504/image/long-stephen.jpg)
Publications Highlights
Delgado B.D. & Long S.B. (2022). Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter. Science Advances
Wang, C.*, Polovitskaya, M.M.*, Delgado, B.D., Jentsch, T. J., & Long, S.B. (2022). Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Science Advances
Jiang, Y., Benz, T. L., & Long, S.B. (2021). Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science
Hou, X.*, Outhwaite, I.R.*, Pedi, L., and Long, S.B. (2020). Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife 9. (Abstract | Open Conformation Cryo-EM map & Atomic Coordinates). *X. Hou and I.R. Outhwaite are co-first authors.
Wang, C., Jacewicz, A., Delgado, B.D., Baradaran, R., and Long, S.B. (2020). Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife 9. (Abstract | Holocomplex Cryo-EM map & Atomic Coordinates | MICU1-MICU2 complex Cryo-EM map & Atomic Coordinates)
People
![Stephen B. Long, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/3845/person/long_190205_13_1200x800.jpg?h=10d202d3)
Stephen B. Long, PhD
Member
- The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.
- BA, Physics, Amherst College, 1994
- PhD, Biochemistry, Duke University, 2001
- Postdoc, Rockefeller University, 2007
- [email protected]
- Email Address
- 212-639-2903
- Office Phone
Members
![Bryce Delgado](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/219457/main_image/delgado-bryce-230215-09_rt_smaller.jpg)
- BS Northeastern University (2018)
![Nandish Khanra](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/266031/main_image/khanra-nandish-230215-40_rt_smaller.jpg)
![Swati Pant](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/266036/main_image/pant-swati-230215-12_rt.jpg)
![Stephanie Woods](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/268551/main_image/stephanie.png)
![Qing Zhang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/268746/main_image/qing.jpg)
![Bryce Delgado](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/219457/main_image/delgado-bryce-230215-09_rt_smaller.jpg)
Graduate Student
![Nandish Khanra](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/266031/main_image/khanra-nandish-230215-40_rt_smaller.jpg)
Senior Research Scientist
![Swati Pant](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/266036/main_image/pant-swati-230215-12_rt.jpg)
Graduate Student
![David J. Van Dongen](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/219442/main_image/david-photo-for-lab-site.jpg)
Graduate Student
![Stephanie Woods](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/268551/main_image/stephanie.png)
Assistant and Lab Coordinator
![Qing Zhang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/268746/main_image/qing.jpg)
Research Scholar
![Pictured: David Kerr](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/19830/3x2/kerr-david_1200x800-copy.jpg?h=10d202d3)
- BA, Amherst College
- MD, Duke University
- Residency: Orthopedic Surgery, Duke University School of Medicine
![Rozbeh Baradaran](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/26806/3x2/baradaran_190205_01_1200x800-1.jpg?h=10d202d3)
- BSc Honours Degree in Biochemistry from The School of Biological Sciences, Queen Mary, University of London (2004)
- PhD in Biochemistry from The Medical Research Council, Mitochondrial Biology Unit (2009)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/219436/main_image/benz-thomas.jpg?h=734e1b13)
- BA, Biology and Mathematics, Williams College (2019)
![Xiaowei Hou, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5363/image/xiaowei2.jpg?h=10d202d3)
- PhD: University of Science and Technology of China - Institute of Biophysics, Chinese Academy of Sciences
- BS: Anhui University - Chemical Engineering)
![Pictured: Alexandria Miller](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5362/3x2/miller_170825_09_1200x800.jpg?h=10d202d3)
- Smith College
![Ian Outhwaite](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/152182/3x2/outhwaite_190205_10_1200x800-1.jpg?h=10d202d3)
- BA, Williams College (May, 2017)
- Stuyvesant High School
![Chongyuan Wang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/152185/3x2/wang_190205_08_1200x800-1.jpg?h=10d202d3)
- PhD, School of Life Sciences, University of Science and Technology of China
Lab Alumni
Postdoctoral Fellow
![Pictured: David Kerr](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/19830/3x2/kerr-david_1200x800-copy.jpg?h=10d202d3)
Undergraduate Researcher
![Rozbeh Baradaran](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/26806/3x2/baradaran_190205_01_1200x800-1.jpg?h=10d202d3)
Postdoc
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/219436/main_image/benz-thomas.jpg?h=734e1b13)
Research Technician
Research Technician
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5360/image/melinda2.jpg)
Graduate Student
![Xiaowei Hou, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5363/image/xiaowei2.jpg?h=10d202d3)
Senior Research Scientist
![Agata Jacewicz](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/173230/3x2/jacewicz_190205_06_1200x800.jpg?h=10d202d3)
Senior Research Scientist
![Yiyang Jiang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/172099/3x2/jiang_190205_09_1200x800-1.jpg?h=10d202d3)
Research Scholar
![Pictured: Alexandria Miller](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5362/3x2/miller_170825_09_1200x800.jpg?h=10d202d3)
Assistant Professor, University of Iowa - Molecular Physiology and Biophysics, Iowa City, IA
![Ian Outhwaite](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/152182/3x2/outhwaite_190205_10_1200x800-1.jpg?h=10d202d3)
Research Technician
![Leanne Pedi](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5359/image/leanne2.jpg)
Senior Research Assistant
Research Technician
![George Vaisey, MBiochem](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/20059/image/george-vaisey.jpg?h=10d202d3)
Graduate Student
![Chongyuan Wang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/152185/3x2/wang_190205_08_1200x800-1.jpg?h=10d202d3)
Postdoctoral Fellow & Senior Research Scientist
Lab Affiliations
Achievements
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
- Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
- Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Postdoctoral Fellow Positions
Get in Touch
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Lab Head Email
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Office Phone
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Stephen B. Long discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].