Developmental Biology Program

The Zhirong Bao Lab

Zhirong Bao, PhD

My lab investigates how the genome dictates development using C. elegans as a model.

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In the Lab

Stained pathology slides of a patient’s tumor (right) and of an organoid made from that tumor (left).

Five Fascinating Approaches to Cancer Science

From tropical plants and 3-D snapshots of worms to tiny particles that light up tumors, here’s a glimpse at some of the fascinating work MSK researchers pursued in 2014 as part of our quest to advance cancer science.

Snapshot

How to Build a Worm, in 3-D High Definition

Stunning movies captured in the lab of computational biologist Zhirong Bao reveal how cells divide, grow, and move around, as in a carefully choreographed dance, during the development of a nematode worm embryo.

Publications Highlights

Wang, Z., Wang, D.*, Li, C., Xu, Y., Li, H. & Bao, Z.* (2018). Deep reinforcement learning of cell movement in the early stage of C. elegans embryogenesis, Bioinformatics, 34, 3169-77

Shah, P.K., Santella, A., Jacobo, A., Siletti, K., Hudspeth, A.J. & Bao, Z. (2017). An in toto approach to dissecting cellular interactions in complex tissues. Dev Cell, 43, 530-540

Shah, P.K., Tanner, M.R., Kovacevic, I., Rankin, A., Marshall, T.E., Noblett, N., Tran, N.N., Roenspies, T., Hung, J., Chen, Z., Slatculescu, C., Perkins, T.J., Bao, Z.* & Colavita, A.* (2017). PCP and SAX-3/Robo pathways cooperate to regulate convergent extension-based nerve cord assembly in C. elegans, Dev Cell, 41, 195-203

Du, Z., Santella, A., He, F., Shah, P.K., Kamikawa, Y. & Bao, Z. (2015). The regulatory landscape of lineage differentiation in a metazoan embryo, Dev Cell, 34, 592-607

Du, Z., Santella, A., He, F., Tiongson, M. & Bao, Z. (2014). De novo inference of systems-level mechanistic models of development from live imaging-based phenotype analysis, Cell, 156, 359-72

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People

Zhirong Bao, PhD

The Bao laboratory investigates how the genome dictates development using C. elegans as a model.
PhD, Washington University

[email protected]: Email Address

Members

Hayao Ohno, PhD — Hayao Ohno
Research Fellow

Yichi Xu, PhD — Yichi Xu
Research Fellow

Anthony Santella
Senior Research Scientist

Lisbelle Adorno

Administrative Assistant

Lab Affiliations

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Zhirong Bao discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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