Xinbo Yang: Publications

The Xinbo Yang Lab

Xinbo Yang: Publications

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Yang X*, Nishimiya D*, Lochte S, Jude KM, Borowska M, Savvides CS, Dougan M, Su L, Zhao X, Piehler J, Garcia KC. (2023) Facile repurposing of peptide-MHC restricted antibodies for cancer immunotherapy. Nat. Biotechnol. 41, 932-943. PMID: 36593402. *Equal contribution

Yang X*, Garner LI*, Zvyagin IV*, Paley MA*, Komech EA, Jude KM, Zhao X, Fernandes RA, Hassman LM, Paley GL, Savvides CS, Brackenridge S, Quastel MN, Chudakov DM, Bowness P, Yokoyama WM, McMichael AJ, Gillespie GM, Garcia KC. (2022) Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature. 612, 771-777. PMID: *Equal contribution

Hoover AR, Kaabinejadian S, Krawic J, Sun X, Naqash AR, Yin Q, Yang X, Garcia KC, Davis MM, Hildebrand WH, Chen WR. (2022) Localized ablative immunotherapy drives de novo CD8+ T-cell responses to poorly immunogenic tumors. J. Immunother. Cancer. 10, e004973. PMID: 36253002.

Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC. Tuning T cell receptor sensitivity through catch bond engineering. Science. 376, eabl5282. PMID: 35389803.

Ali M, Giannakopoulou E, Li Y, Lehander M, Culleton SV, Yang W, Knetter C, Odabsai MC, Bollineni RC, Yang X, Foldvari Z, Boschen ML, Taraldsrud E, Stronen E, Toebes M, Hillen A, Mazzi S, H de Ru A, Janssen G, Kolstad N, Tjonnfjord GE, Lie BA, Griffioen M, Lehmannn S, Osnes LT, Buechner J, Garcia KC, Schumacher TN, van Veelen PA, Leisegan M, Jacobsen SEW, Woll P, Olweus J. (2021) T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes. Nat. Biotechnol. 40, 488-498. PMID: 34873326.

Chiou SH, Tseng D, Reuban A, Mallajosyula V, Molina IS, Conley S, Wihelmy J, McSween AM, Yang X, Nishimiya D, Sinha R, Nabet BY, Wang C, Shrager JB, Berry MF, Berry GJ, Delaidelli A, Sorensen PH, Sotillo E, Tran P, Benson JA, Richards R, Labanieh L, Klysz DD, Louis DM, Feldman SA, Diehn M, Weissman IL, Zhang J, Wistuba II, Futreal PA, Heymach JV, Garcia KC, Mackall CL, Davis MM. (2021) Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery. Immunity. 54, 586-602. PMID: 33691136

Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg, SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC. (2020) Immune receptor inhibition through enforced phosphatase recruitment. Nature. 586, 779-784. PMID: 33087934

Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC. (2020) Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo. Elife. 9, e58463. PMID: 32773038

Gee MH, Sibener LV, Birnbaum ME, Jude KM, Yang X, Fernandes RA, Mendoza JL, Glassman CR, Garcia KC. (2018) Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. Proc. Natl. Acad. Sci USA. 115, E7369-7378. PMID: 30021852

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su, LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA, Heath JR, Evavold BD, Vale RD, Garcia KC. (2018) Isolation and visualization of a structural trigger that uncouples TCR signaling from pMHC binding. Cell. 174, 672-687. PMID: 30053426

Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake S, Davis MM, Garcia KC. (2018) Antigen identification for orphan T cell receptors expressed on tumor infiltrating lymphocytes. Cell. 172, 549-563. PMID: 29275860

Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, Mueller S, Pollack IF, Rajalingam R, Carcaboso AM, Mann M, Sette A, Garcia KC, Hou Y, Okada H. (2017) Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy. J. Exp. Medicine. 215, 141-157. PMID: 29203539

Chen G, Yang X, Ko A, Sun X, Gao M, Zhang Y, Shi A, Mariuzza RA, Weng N-P. (2017) Sequence and structural analyses reveal distinct and highly diverse human CD8+ TCR repertoires to immunodominant viral antigens. Cell reports. 19, 569-583. PMID: 28423320

Yang X, Chen G, Weng N-P, Mariuzza RA. (2017) Structural basis for clonal diversity of the human T cell response to a dominant influenza virus epitope. J. Biol. Chem. 292, 18618-18627. PMID: 28931605

Yang X, Gao M, Chen G, Pierce B, Lu J, Weng N-P, Mariuzza RA. (2015) Structural basis for clonal diversity of the human T cell response to a dominant human cytomegalovirus epitope. J. Biol. Chem. 290, 29106-29119. PMID: 26429912

Yang X, Mariuzza RA. (2015) Pre-T-Cell Receptor Binds MHC: Implications for Thymocyte Signaling and Selection. Proc. Natl. Acad. Sci. USA. 112, 8166-8167. PMID: 26134398

Luo M, Velikovsky CA, Yang X, Siddigui MA, Hong X, Barchi JJ Jr, Gildersleeve JC, Pancer Z, Mariuzza RA. (2013) Recognition of the Thomsen-Friedenreich Pancarcinoma Carbohydrate Antigen by a Lamprey Variable Lymphocyte Receptor. J. Biol. Chem. 288, 23597-23606. PMID: 23782692

Yang X, Wang Y, Lu Z, Zhai L, Jiang J, Liu J, Yu H. (2009) A novel serine protease inhibitor from the venom of Vespa bicolor Fabricius. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 153, 116-120. PMID: 19258046

Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H. (2008) Antimicrobial peptides from the venoms of Vespa bicolor Fabricius. Peptides. 29, 1887-1892. PMID: 18723059

Han Y, Yu H, Yang X, Rees HH, Liu J, Lai R. (2008) A serine proteinase inhibitor from frog eggs with bacteriostatic activity. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 149, 58-62. PMID: 17826205