Immunology Program

The Andrea Schietinger Lab

Andrea Schietinger, PhD

Catherine and Frederick R. Adler Chair for Junior Faculty

The goal of our laboratory is to understand when, why, and how immune cells become unresponsive to tumors or self-destructive in autoimmune diseases. We develop genetic cancer mouse models that mimic cancer development in patients, investigate T cell responses over the course of tumor development, and define the molecular mechanisms that are responsible for the failure to control and eliminate tumors. In addition, we utilize clinically relevant mouse models of autoimmunity, such as Type 1 Diabetes, to understand how autoimmune responses are initiated and sustained. Our ongoing and future research programs aim to develop a deep mechanistic understanding of the spatiotemporal, molecular, and epigenetic factors that determine T cell fate decisions and functional/dysfunctional states in cancer and autoimmunity, and test innovative conceptual frameworks and T cell reprogramming approaches for the treatment of T cell-mediated diseases. Detailed information about our research is available at www.schietingerlab.com.

Featured News

Discovery of a Stem-like T Cell in Type 1 Diabetes Holds Potential for Improving Cancer Immunotherapy, Sloan Kettering Institute Scientists Say

As an autoimmune disease, Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy.

Sloan Kettering Institute Year in Review: 10 Noteworthy Science Breakthroughs of 2021

Take a look back at some of the biggest science stories from this past year.

In the Lab

Scientists at the Sloan Kettering Institute are learning why some immune cells are stubbornly hard to revive with immunotherapy.

Why Immune Cells Sometimes Fail to Fight Cancer (and What to Do about It)

By looking at how DNA is packaged in cells, scientists are teasing apart a long-standing conundrum about the immune response to cancer.

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Publications Highlights

Gearty SV, Dündar F, Zumbo P, Espinosa-Carrasco G, ShakibaM, Sanchez-RiveraF, SocciND, Trivedi D, LoweSW, LauerP, Mohibullah N, DiLorenzo TP, Viale A, Betel D, Schietinger A. A stem-like autoimmune CD8 T cell population drives type 1 diabetes. Nature 2022 Feb;602(7895):156-161.

Shakiba M, Zumbo P, Dündar F, Espinosa-Carrasco G, Camara S, Sanchez-Rivera FG, Lowe SW, Koche RP, Reuter VP, Socci ND, Whitlock B, Tamzalit F, Huse M, Betel D, Philip M, Schietinger A. TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. Journal of Experimental Medicine 2022 Feb 7;219(2):e20201966.

Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer. Nature Reviews Immunology. 2022 Apr;22(4):209-223.

TOX is a critical regulator of tumour-specific T cell differentiation. Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A. Nature. 2019 Jul;571(7764):270-274. doi: 10.1038/s41586-019-1324-y. Epub 2019 Jun 17.

Chromatin states define tumour-specific T cell dysfunction and reprogramming. Philip M, Fairchild L, Sun L, Horste EL, Camara S, Shakiba M, Scott AC, Viale A, Lauer P, Merghoub T, Hellmann MD, Wolchok JD, Leslie CS, Schietinger A. Nature. 2017 May 25;545(7655):452-456. doi: 10.1038/nature22367. Epub 2017 May 17.

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People

Andrea Schietinger, PhD

Catherine and Frederick R. Adler Chair for Junior Faculty

Cancer Immunologist Andrea Schietinger investigates immune responses to cancer, molecular mechanisms underlying tumor-induced T cell dysfunction, and new approaches for cancer immunotherapy.
PharmD, University of Hamburg, PhD, University of Chicago, Chicago, IL and University of Munich, Germany
Postdoctoral Training: Fred Hutchinson Cancer Research Center and University of Washington, Seattle

[email protected]: Email Address
646-888-3754: Office Phone

Members

Andrea Schietinger

Principal Investigator, Associate Member

Katrina Hawley
PhD - Postdoctoral Fellow

Nadine Hernandez
Senior Administrative Assistant

Joseph Palmeri
PhD - Postdoctoral Fellow

Lab Alumni

Varintra Krisnawan

Research Technician

Mary Philip, MD PhD — Mary Philip
Senior Research Scientist

Nayanta Buchanan
Administrative Assistant

Heather Appleby, Research Technician — Heather Appleby
Research Technician

Gabriel Espinosa-Carrasco
Postdoctoral Fellow

Prerak Trivedi, Research Fellow — Prerak Trivedi
Postdoctoral Fellow

Lab Affiliations

Achievements

AACR-Irving Weinstein Foundation Distinguished Lectureship Award (2023)
American Association of Immunologists - AAI BD Biosciences Investigator Award (2022)
AACR-Bristol Myers Squibb Midcareer Female Investigator Award (2021)
Catherine and Frederick R. Adler Chair for Junior Faculty (2021)
Louise and Allston Boyer Young Investigator Award for Basic Research (2020)

Pershing Square Sohn Award (2020)
Josie Robertson Investigator (2014-2019)
Cancer Research Institute Lloyd Old STAR Award (2019)
NIH Director’s Innovator Award (2017)
NIH/NCI K99/R00 Award (2015)
V Foundation for Cancer Research Award (2015)
William and Ella Owens Medical Research Foundation Award (2016)
Cancer Research Institute Irvington Fellowship (2012)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Tumor Immunology

Apply now

Get in Touch

[email protected]

Lab Head Email
646-888-3754

Office Phone
646-422-0502

Office Fax
646-888-2635

Assistant: Nadine Hernandez
646-888-3334

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Andrea Schietinger discloses the following relationships and financial interests:

American Association for Cancer Research
Professional Services and Activities (Uncompensated)
CICON International Cancer Immunotherapy Conference
Professional Services and Activities (Uncompensated)
Cold Spring Harbor Laboratory
Professional Services and Activities (Uncompensated)
Federation of American Societies for Experimental Biology (FASEB)
Professional Services and Activities (Uncompensated)

Immunology of Diabetes Society (IDS)
Professional Services and Activities (Uncompensated)
Immunotherapy of Cancer Conference (ITOC)
Professional Services and Activities (Uncompensated)
MD Anderson
Professional Services and Activities (Uncompensated)

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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