Computational & Systems Biology Program
The Joao Xavier Lab
Research
![Joao Xavier](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5322/main_image/xavier-joao-240717-14_rtc_1200x800.jpg?h=10d202d3)
We combine computation and experiment to investigate how cells interact with each other to produce complex cell group behaviors.
![Xavier Lab](https://www.mskcc.org/sites/default/files/node/5322/images/screenshot-2024-08-07-at-12.41.02-pm.png)
Featured News
![Systems biologist Joao Xavier in his lab](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/213604/main_image/xavier-lab_201119_008_rt-1200x800.jpg)
![Joao Xavier](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/5518/image/491787.jpg)
![Pictured: Eric Pamer & Joao Xavier](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/30033/image/pamer-and-xavier.jpg)
Publications Highlights
Liao C, Rolling T, Djukovic A, Fei T, Mishra V, Liu H, Lindberg C, Dai L, Zhai B, Peled JU, Brink MRMvd, Hohl TM, Xavier JB. A high fraction of oral bacteria in the feces indicates gut microbiota depletion with implications for human health. bioRxiv. 2023:2022.10.24.513595. doi: 10.1101/2022.10.24.513595. (Accepted for publication in Nature Microbiology)
Mathur D, Liao C, Lin W, La Ferlita A, Alaimo S, Taylor S, Zhong Y, Iacobuzio-Donahue C, Ferro A, Xavier JB. The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung. Cancer Res. 2023 Oct 13;83(20):3478-3491. doi: 10.1158/0008-5472.CAN-23-0153. PMID: 37526524; PMCID: PMC10570685.
Schluter J, Djukovic A, Taylor BP, Yan J, Duan C, Hussey GA, Liao C, Sharma S, Fontana E, Amoretti LA, Wright RJ, Dai A, Peled JU, Taur Y, Perales MA, Siranosian BA, Bhatt AS, van den Brink MRM, Pamer EG, Xavier JB. The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia. Cell Host Microbe. 2023 Jul 12;31(7):1126-1139.e6. doi: 10.1016/j.chom.2023.05.027. Epub 2023 Jun 16. PMID: 37329880; PMCID: PMC10527165.
Santamaria G, Liao C, Lindberg C, Chen Y, Wang Z, Rhee K, Pinto FR, Yan J, Xavier JB. Evolution and regulation of microbial secondary metabolism. Elife. 2022 Nov 21;11:e76119. doi: 10.7554/eLife.76119. PMID: 36409069; PMCID: PMC9708071.
Schluter J, Peled JU, Taylor BP, Markey KA, Smith M, Taur Y, Niehus R, Staffas A, Dai A, Fontana E, Amoretti LA, Wright RJ, Morjaria S, Fenelus M, Pessin MS, Chao NJ, Lew M, Bohannon L, Bush A, Sung AD, Hohl TM, Perales MA, van den Brink MRM, Xavier JB. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020 Dec;588(7837):303-307. doi: 10.1038/s41586-020-2971-8. Epub 2020 Nov 25. PMID: 33239790; PMCID: PMC7725892.
People
![Joao Xavier](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/5322/main_image/xavier-joao-240717-14_rtc_1200x800.jpg?h=10d202d3)
Joao Xavier, PhD
Member, Computational & Systems Biology Program
- Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.
- PhD, Universidade Nova de Lisboa
- xavierj@mskcc.org
- Email Address
- 646-888-3195
- Office Phone
Members
![Andras](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/284431/main_image/bimbo-szuhai_-andras-240717-06_rtc_1200x800_720.jpg?h=34e43602)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/307196/main_image/han-qixiu-240717-03_rtc.jpg)
![Heesoo](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/284436/main_image/jeong-heesoo-240717-02_rtc_1200x800.jpg)
![Diego](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/307191/main_image/headshot-diegokaune.jpg)
![Sharon Li](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/313941/main_image/_dsc2446_720.jpg)
![Chen Liao](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/172096/3x2/chen_190207_06_1200x800.jpg)
![Sneh](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/261686/main_image/screenshot-2024-08-07-at-12.42.21-pm.png)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/313936/main_image/screenshot_2025-02-17_at_11.54.36___am_720.png)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/261671/main_image/wucher_photo.png)
![Andras](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/284431/main_image/bimbo-szuhai_-andras-240717-06_rtc_1200x800_720.jpg?h=34e43602)
Research Technician
![Ana Djokovic](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154807/main_image/djukovic_-ana-240717-04_rtc_1200x1200.jpg?h=cd2a7045)
Senior Research Scientist
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/320636/main_image/screenshot-2025-01-30-at-3.18.27-pm.png)
Administrative Assistant
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/307196/main_image/han-qixiu-240717-03_rtc.jpg)
Graduate Student
![Heesoo](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/284436/main_image/jeong-heesoo-240717-02_rtc_1200x800.jpg)
Research Scholar
![Diego](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/307191/main_image/headshot-diegokaune.jpg)
Research Technician
![Sharon Li](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/313941/main_image/_dsc2446_720.jpg)
Research Technician
![Chen Liao](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/172096/3x2/chen_190207_06_1200x800.jpg)
Research Scholar
![Deepti Mathur](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154804/3x2/mathur_190205_09_1200x800.jpg)
Postdoctoral Research Fellow
![Vishwas Mishra](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/243175/main_image/mishra-vishwas-220330-014_1200x800.jpg)
Graduate Student
![Sneh](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/261686/main_image/screenshot-2024-08-07-at-12.42.21-pm.png)
Lab Manager
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/313936/main_image/screenshot_2025-02-17_at_11.54.36___am_720.png)
Computational Biologist
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/261671/main_image/wucher_photo.png)
Research Scholar
![Henri Estanbouli](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154873/3x2/estanbouli_190205_07_1200x800-1.jpg?h=10d202d3)
Lab Alumni
Research Scholar
Graduate Student
![Nathaniel Campbell](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154813/3x2/campbell_190205_05_1200x800-1.jpg?h=10d202d3)
Graduate Student
Graduate Student
![Yanyan Chen](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/243172/main_image/chen-yanyan-220330-003_1200x800.jpg?h=10d202d3)
Research Scholar
Graduate Student
Postdoctoral Research Fellow
![Henri Estanbouli](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154873/3x2/estanbouli_190205_07_1200x800-1.jpg?h=10d202d3)
Laboratory Technician
Admin Assistant II
Research Fellow
Postdoctoral Research Fellow
![Trinasia Kelly](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/243178/main_image/kelly-trinasia-220330-013_1200x800.jpg?h=10d202d3)
Administrative Assistant
![Wendy Lin](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/218758/main_image/lin-wendy-240717-01_rtc_1200x800.jpg?h=10d202d3)
Graduate Student
Laboratory Technician
![Jonas Schlueter](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154801/3x2/schlueter-jonas_180423_13_1200x800.jpg?h=10d202d3)
Postdoctoral Research Fellow
Research Fellow
![Bradford Taylor](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/154810/3x2/taylor_190205_07_1200x800-1.jpg?h=10d202d3)
Postdoctoral Research Fellow
Postdoctoral Research Fellow
![Jinyuan Yan](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/24942/3x2/yan_190207_07_1200x800-1.jpg?h=10d202d3)
Postdoctoral Research Fellow
Lab Affiliations
Achievements
- Director's New Innovator Award, National Institutes of Health (2011)
- Biofilm Young Investigator Award, Center for Biofilm Engineering (2010)
Lab News & Events
Upcoming event
Using AI/ML for Molecular Design and Metabolite Elucidation
Memorial Sloan Kettering Cancer Center
1275 York Avenue
Room M-107
New York, NY 10065
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
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Office Phone
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Lab Phone
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Joao Xavier discloses the following relationships and financial interests:
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Oficina Design
Fiduciary Role / Position
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.