Structural Biology Program

The Richard Hite Lab

Richard Hite, PhD

Our research group has two primary focuses. One part of the lab focuses on determining the mechanisms of intracellular ion and metabolite transport, while the second studies protein nucleic acid interactions that are critical for maintaining genomic integrity. We study these fundamental processes using a variety of cell biological, biochemical, structural and biophysical tools including cryo-electron microscopy and electrophysiology.

Structure of the lysosomal chloride-proton transporter CLC-7 in complex with OSTM1

Structure of the 9-1-1 checkpoint clamp being loaded onto DNA by the 9-1-1 checkpoint clamp

Featured News

SKI Scientists Determine Structure of a DNA Damage 'First Responder'

The results of this collaborative project overturn some conventional wisdom about how the DNA repair process works.

Publications Highlights

Son Y., Kenny T.C., Khan A., Birsoy K., & Hite R.K. (2024). “Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1.” Nature.

Paknejad N., Sapuru V., & Hite R.K. (2023) “Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor.” Nat Commun. 14(1):6897.

Oh S., Stix R., Zhou W., Faraldo-Gómez J.D., & Hite R.K. (2022). “Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.” Proc Natl Acad Sci U S A. 119(44):e2208882119.

Schrecker M., Castaneda J.C., Devbhandari S., Kumar C., Remus D., & Hite R.K. (2022). “Multistep loading of a DNA sliding clamp onto DNA by replication factor C.” eLife. 11:e78253.

Castaneda J.C., Schrecker M., Remus D., & Hite R.K. (2022). “Mechanisms of loading and release of the 9-1-1 checkpoint clamp.” Nat Struct Mol Biol. 29(4):369-375.

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People

Richard Hite, PhD

The Hite laboratory studies the mechanisms of ion and metabolite transport and the maintenance of genomic integrity.
BS, Emory University
PhD, Harvard University

Members

Brandon Malone

Research Fellow

Alexander Payne

Graduate Student

Yeeun Jecy Son

Graduate Student

Lab Alumni

Kadeem P. Ho Sang
Administrative Research Assistant

Changrui Xing

Research Fellow

Lab Affiliations

Achievements

Pershing Square Sohn Prize for Young Investigators in Cancer Research
Josie Robertson Investigator (2017-2022)
Searle Scholar
Tri-Institutional Breakout Award for Junior Investigators

Open Positions

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Graduate Students & Postdoctoral Fellows

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Richard Hite discloses the following relationships and financial interests:

Cerevel Therapeutics
Professional Services and Activities
Roche
Professional Services and Activities

Vesalius Therapeutics
Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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