Structural Biology Program

The Stephen Long Lab

Stephen B. Long, PhD

Member, Structural Biology Program

Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development, and they are potential targets for diseases including immune disorders and cancer. Our discoveries lead to new understandings of the fundamental mechanisms of the ion channels and enzymes. These understandings also guide our efforts to develop and evaluate small molecule and biologic modulators for therapeutic potential for cancer and other diseases.

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Voltage-dependent potassium channel and Two-pore domain potassium channel

X-ray structures of eukaryotic calcium, potassium, and chloride channels determined in the lab

Pictured: Stephen B Long Lab — Long Lab circa 2021

Featured News

Sloan Kettering Institute Year in Review: 10 Noteworthy Science Breakthroughs of 2021

Take a look back at some of the biggest science stories from this past year.

In the Lab

A gray blob marked RAS linked to colorful rods marked ICMT

Deciphering How Membrane Enzymes Work, with a Little Help from Beetles

The atomic structure of an elusive type of membrane protein has finally been solved by scientists at the Sloan Kettering Institute.

Profile

Pictured: Stephen Long & Alexandria Miller

At Work: Structural Biologist Stephen Long

Stephen Long works to understand how proteins work by determining what they look like in three dimensions.

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Publications Highlights

Delgado B.D. & Long S.B. (2022). Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter. Science Advances

Wang, C.*, Polovitskaya, M.M.*, Delgado, B.D., Jentsch, T. J., & Long, S.B. (2022). Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Science Advances

Jiang, Y., Benz, T. L., & Long, S.B. (2021). Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science

Hou, X.*, Outhwaite, I.R.*, Pedi, L., and Long, S.B. (2020). Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife 9. (Abstract | Open Conformation Cryo-EM map & Atomic Coordinates). *X. Hou and I.R. Outhwaite are co-first authors.

Wang, C., Jacewicz, A., Delgado, B.D., Baradaran, R., and Long, S.B. (2020). Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife 9. (Abstract | Holocomplex Cryo-EM map & Atomic Coordinates | MICU1-MICU2 complex Cryo-EM map & Atomic Coordinates)

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People

Stephen B. Long, PhD

Member, Structural Biology Program

The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.
BA, Physics, Amherst College, 1994
PhD, Biochemistry, Duke University, 2001
Postdoc, Rockefeller University, 2007

[email protected]: Email Address
212-639-2903: Office Phone

Members

Bryce Delgado — Bryce D. Delgado
Graduate Student

Nandish Khanra — Nandish Kumar Khanra
Senior Research Scientist

Stephanie Woods
Assistant and Lab Coordinator

Lab Alumni

Veronica Kane-Dickson

Postdoctoral Fellow

Pictured: David Kerr — David Kerr
Undergraduate Researcher

Shana Burstein

Research Technician

Xiaowei Hou, PhD — Xiaowei Hou
Senior Research Scientist

Agata Jacewicz
Senior Research Scientist

Pictured: Alexandria Miller — Alexandria N. Miller
Assistant Professor, University of Iowa - Molecular Physiology and Biophysics, Iowa City, IA

Nicole Trezza

Research Technician

George Vaisey, MBiochem — George Vaisey
Graduate Student

Chongyuan Wang
Postdoctoral Fellow & Senior Research Scientist

Lab Affiliations

Achievements

Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Postdoctoral Fellow Positions

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Get in Touch

[email protected]

Lab Head Email
212-639-2903

Office Phone
212-639-2959

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Stephen B. Long discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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