Computational & Systems Biology Program

The Thomas Norman Lab

Thomas Norman, PhD

The Norman Lab aims to combine large-scale functional genomics experiments with computational modeling to enable rational engineering of cell state. Our primary model system is the fibroblast, a ubiquitous and phenotypically plastic cell type that plays a role in diverse pathologies. We played a foundational role in developing the Perturb-seq approach for single-cell CRISPR screening and continue to develop new approaches to enable functional genomics experiments beyond genome-scale. Our ultimate goal is to learn principles for precisely controlling cellular behavior, with potential applications in cell therapy and disease modeling.

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Publications Highlights

Replogle, J.M.*, Saunders, R.A.*, Pogson, A.N., Hussmann, J.A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E.J., Adelman, K., Bonnar, J.L., Jost, M., Norman, T.M.† and Jonathan S Weissman.† Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell vol. 185 2559-2575.e28 (2022).

Norman, T.M.*, Horlbeck, M.*, Replogle, J., Ge, A., Xu, A., Jost, M., Gilbert, L., & Weissman, J.S. Exploring genetic interaction manifolds constructed from rich phenotypes. Science 365, 786-793 (2019).

Adamson, B.*, Norman, T.M.*, Jost, M., Cho, M.Y., Nuñez, J.K., Chen, Y., Villalta, J.E., Gilbert, L.A., Horlbeck, M.A., Hein, M.Y. Pak, R.A., Gray, A.N., Gross, C.A., Dixit, A. Parnas, O., Regev, A. & Weissman, J.S. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response. Cell 167, 1867-1882 (2016).

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People

Thomas Norman, PhD

Systems biologist Thomas Norman develops new computational and functional genomics approaches for studying how genes interact to realize complex phenotypes.
PhD, Harvard University

[email protected]: Email Address

Members

Ashleigh Donnellan
Administrative Assistant, Sr.

Lab Alumni

Rafaela Mendes

Laboratory Technician

Lab Affiliations

Achievements

Josie Robertson Investigator (2019-2024)
Damon Runyon-Dale F. Frey Award for Breakthrough Scientists (2019)
Damon Runyon Cancer Research Foundation Fellowship (2015-2018)
NIH Director's New Innovator Award (2020)

Open Positions

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Get in Touch

[email protected]

Lab Head Email

Lab Resources

Please contact:

Ashleigh Donnellan

Administrative Assistant

[email protected]

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Thomas Norman discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

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