Cryo-Electron Microscopy Innovation Laboratory (CEMIL)

In conjunction with the Structural Biology Core Facility, CEMIL enables practitioners of Cryo-EM within MSK laboratories to design innovative experiments and collect the highest quality Cryo-EM data that moves their research forward. The facility includes two Titan Krios microscopes (G2 and G4 generation) housed within precision-controlled environments in the Rockefeller Research Laboratory. The microscopes are equipped with direct electron detectors (Gatan K3 and Thermo Falcon 4i) to enable atomic resolution visualization of biological samples. A Selectris X energy filter facilitates high signal-to-noise data collection. Training in Cryo-EM is available through MSK’s membership in the New York Structural Biology Center.

Dr. Stephen Long, Director of CEMIL, is an expert in structural biology and membrane protein biophysics. His research combines cryo-electron microscopy, x-ray crystallography, and electrophysiology to uncover the molecular mechanisms of eukaryotic ion channels and membrane-embedded enzymes. As Director, Dr. Long provides scientific leadership for CEMIL, ensuring that MSK investigators have access to state-of-the-art Cryo-EM instrumentation, cutting-edge methodologies, and expert guidance for structure determination. Under his direction, CEMIL fosters collaboration among researchers, supports the development of new imaging workflows, and advances MSK’s capabilities in high-resolution electron microscopy.

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