Journal Club 2022

Journal Club 2022

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December 2022

12/15/22

Presented by Zita Aretz

“Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.”

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November 2022

11/17/22

Presented by Jaeyop Lee

“Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy.”

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11/10/22

Presented by Kristen Vogt

“Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.”

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September 2022

9/29/22

Presented by Pedro Silberman

“Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory.”

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9/22/22

Presented by Manish Malviya

“A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease.”

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9/1/22

Presented by Keifer Kurtz

“SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling.”

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August 2022

8/18/22

Presented by Zaki Molvi

“T cells discriminate between groups C1 and C2 HLA-C.”

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8/11/22

Presented by Michael Lau

“Antigen cross-presentation in young tumor-bearing hosts promotes CD8+ T cell terminal differentiation.”

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June 2022

6/09/22

Presented by James Han

“Neoantigen T-Cell Receptor Gene Therapy in Pancreating Cancer.”

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6/02/22

Presented by Patrick Wallisch

“The immunostimulatory RNA RN7SL1 enables CAR T cells to enhance autonomous and endogenous immune function.”

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May 2022

5/05/2022

Presented by Winson Cai

A genome-scale screen for synthetic drivers of T cell proliferation.”

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April 2022

4/28/2022

Presented by Kristen Vogt  

“Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities.”

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“Preclinical Efficacy and Safety of CD19CAR Cytokine-Induced Killer Cells Transfected with Sleeping Beauty Transposon for the treatment of Acute Lymphoblastic Leukemia.”

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4/21/2022

Presented by Zita Aretz

“Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.” 

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4/14/2022

Presented by Shireen Khayat 

“SIRPy-CD47 Interaction Positively Regulates the Activation of Human T Cells in Situation of CHronic Stimulation.”

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March 2022

3/17/2022

Presented by Zaki Molvi  

“CRISPR activation and interference screens decode stimulation responses in primary human T cells.” 

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“Targeting an alternate Wilms’ tumor antigen 1 peptide bypasses immunoproteasome dependency.” 

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February 2022

2/10/2022

Presented by Pedro Cito Silberman 

“A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors.” 

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January 2022

1/13/2022

Presented by Winson Cai 

“A human orthogonal IL-2 and IL-2R system enhances CAR T cell expansion and antitumor activity in amurine model of leukemia.”

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1/06/2022

Presented by Anqi [Nora] Zhou

“Natural killer cell receptors regulate responses of HLA-E-restricted T cells.”

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