Samuel Kaplan

Mentor

Start Year

2018

Education

BS, Northeastern University

Samuel Kaplan graduated from Northeastern University with a degree in Biochemistry. Following a co-op at Rubius Therapeutics, he joined the manufacturing group of the organization for the next two years. He worked on erythrocyte differentiation protocol development, scale-up, characterization, and designed a new filtration system to remove nucleated cells and pyrenocytes from the culture. Inspired by the potential of stem cell differentiation for both basic research and clinical translation, Sam found the Huangfu lab especially well-suited among an extensive list of accomplished groups.

Fellowships

T32 training grant in Molecular & Cell Biology (2019-2021)

Publications

Genetic Engineering of Immune Evasive Stem Cell-Derived Islets. Sackett SD, Kaplan SJ, Mitchell SA, Brown ME, Burrack AL, Grey S, Huangfu D, Odorico J.Transpl Int. 2022 Dec 5;35:10817. doi: 10.3389/ti.2022.10817. eCollection 2022.PMID: 36545154

CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. [PMID: 35787684]