Xianming Wang, PhD

Research Fellow
The Danwei Huangfu Lab
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Xianming Wang, PhD

Research Fellow
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Xianming Wang

Mentor

Danwei Huangfu, PhD

Start Year

2023

Education

PhD, Helmholtz Zentrum München German Research Center for Environmental Health

Xianming Wang is an accomplished researcher originally from China. He earned his Master’s degree from the University of Science and Technology of China in 2011 and went on to complete his Doctoral studies at the Technical University of Munich in Germany in 2020. With a diverse range of expertise, he has worked extensively with stem cells, gene editing, disease modeling, stem cell-derived islets, and 3D organoid culture. As a member of the Huangfu lab, his research is focused on discovering new targets for beta cell regeneration and therapy.

 

Publications

Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells. Shahryari A, Moya N, Siehler J, Wang X, Burtscher I, Lickert H.CRISPR J. 2021 Aug;4(4):491-501. doi: 10.1089/crispr.2021.0014.PMID: 34406042

Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8). Siehler J, Blöchinger AK, Akgün M, Wang X, Shahryari A, Geerlof A, Lickert H, Burtscher I. Stem Cell Res. 2020 Dec 16;50:102126. doi: 10.1016/j.scr.2020.102126. Online ahead of print.PMID: 33373890 

Generation of a human iPSC line harboring a biallelic large deletion at the INK4 locus (HMGUi001-A-5) Shahryari A, Moya N, Siehler J, Wang X, Karolina Blöchinger A, Burtscher I, Bakhti M, Mowla SJ, Lickert H. Stem Cell Res. 2020 Jul 25;47:101927. doi: 10.1016/j.scr.2020.101927. Online ahead of print.PMID: 32739881 

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual. Wang X, Malinowski AR, Beckenbauer J, Siehler J, Blöchinger A, Meitinger T, Häring HU, Staiger H, Burtscher I, Lickert H. Stem Cell Res. 2019 Aug;39:101531. doi: 10.1016/j.scr.2019.101531. Epub 2019 Aug 7.PMID: 31419739 

Point mutations in the PDX1 transactivation domain impair human β-cell development and function. Wang X, Sterr M, Ansarullah, Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H. Mol Metab. 2019 Jun;24:80-97. doi: 10.1016/j.molmet.2019.03.006. Epub 2019 Mar 20.PMID: 30930126 

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors. Wang X, Sterr M, Burtscher I, Chen S, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Cernilogar FM, Schotta G, Irmler M, Beckers J, Hrabě de Angelis M, Ray M, Wright CVE, Bakhti M, Lickert H. Mol Metab. 2018 Mar;9:57-68. doi: 10.1016/j.molmet.2018.01.011. Epub 2018 Jan 31.PMID: 29396371 

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Lickert H. Stem Cell Res. 2016 Sep;17(2):292-295. doi: 10.1016/j.scr.2016.08.005. Epub 2016 Aug 6.PMID: 27879214 

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene. Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Lickert H. Stem Cell Res. 2016 Sep;17(2):273-276. doi: 10.1016/j.scr.2016.08.004. Epub 2016 Aug 5.PMID: 27879211 

Urine as a source of stem cells. Benda C, Zhou T, Wang X, Tian W, Grillari J, Tse HF, Grillari-Voglauer R, Pei D, Esteban MA. Adv Biochem Eng Biotechnol. 2013;129:19-32. doi: 10.1007/10_2012_157.PMID: 23038280 

Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA. Hum Mol Genet. 2012 Jan 1;21(1):32-45. doi: 10.1093/hmg/ddr435. Epub 2011 Sep 23.PMID: 21949351

Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome Yang J, Cai J, Zhang Y, Wang X, Li W, Xu J, Li F, Guo X, Deng K, Zhong M, Chen Y, Lai L, Pei D, Esteban MA. J Biol Chem. 2010 Dec 17;285(51):40303-11. doi: 10.1074/jbc.M110.183392. Epub 2010 Oct 18.PMID: 20956530