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CAR T Cells More Powerful When Built With CRISPR, MSK Researchers Find

MSK researchers used the genome-editing tool CRISPR to create more potent chimeric antigen receptor (CAR) T cells that don't tire as easily when attacking cancer cells. The unexpected findings were published in the journal Nature on February 22 and underscore the potential of genome editing to advance immunotherapy for cancer.
In the Lab
CAR T cells attacking cancer
CRISPR Genome-Editing Tool Takes Cancer Immunotherapy to the Next Level

What do you get when you combine two of the hottest areas of biotechnology? A new paper from MSK researchers explains.
In the Lab
Medical illustration of nanoparticle spheres attacking cancer cell, which is beginning to disintegrate.
Nanoparticles Help Drugs Target Head and Neck Cancers with Reduced Side Effects

Researchers devised a novel method to ferry drugs to head and neck cancers using nanoparticles that naturally stick to a protein in tumor blood vessels.
In the Lab
Histology images of stem cells and AML cells
Step by Step: Stem Cell Approach Provides New Models for Studying How Acute Myeloid Leukemia Progresses

A new laboratory tool will allow researchers to study the progression from normal cells to myelodysplastic syndromes to an aggressive type of leukemia.
In the Lab
MSK scientists Charles Rudin and John Poirier
Scientists Home in on Treatment Advance for Chemotherapy-Resistant Small Cell Lung Cancer

An epigenetic mechanism may make small cell lung cancer vulnerable to a new kind of attack.
In the Lab
Cortical neurons derived from human pluripotent stem cells
A 'Quick-and-Easy' Recipe for Making Brain Cells

Using stem cells, scientists can create batches of cortical neurons to study schizophrenia and autism.
Science Byte
Illustration of DNA with green wrench making adjustments to a nut on the double helix.
A Clean Break: Scientists Make Surprising Discoveries about DNA Repair

A study reveals unexpected insights into how cells prepare broken DNA strands to be rejoined, preventing mutations that can cause cancer.
In the Lab
PET/CT scan of mouse prostate (displayed in green and orange).
More Precise Imaging of Prostate Cancer Could Give Insight into Drug Effectiveness

An antibody that targets a protein specific to prostate cells can be used to image prostate cancer more clearly and indicate how well drugs are working.
Feature
T cells on the loose.
T Is for T Cell: The Science Behind Immunotherapy

By deciphering the biology of T cells, MSK scientists gave immunotherapy a boost.
In the Lab
Image of fireball-type explosion on black background.
Researchers Gain Insight into How a Drug Fires Up an Immune Response to Cancer

Scientists have learned that a drug activates a form of highly inflammatory programmed cell death called pyroptosis — a discovery that sheds light on immune function.