Full Title
A Phase 1, Multicenter, Open-label Study to Evaluate the Safety and Preliminary Efficacy of BMS-986393 in Novel Combinations in Participants with Relapsed and/or Refractory Multiple Myeloma and Determine the Recommended Dose for Each Add-on Investigational ComponentPurpose
Researchers want to find the best dose of BMS-986393 to use with other drugs to treat multiple myeloma. The people in this study have multiple myeloma that keeps growing or came back after treatment.
BMS-986393 is a form of chimeric antigen receptor (CAR) T cell therapy, a type of cellular immunotherapy. With CAR T cell therapy, white blood cells called T cells are removed from your body. The T cells are altered in a lab to recognize proteins on your cancer cells. They are then multiplied to larger numbers and returned to your body to find and destroy cancer cells. BMS-986393 is given intravenously (by vein).
Doctors believe that giving BMS-986393 with other medications will be more effective against multiple myeloma than BMS-986393 alone. If you join this study, you will get BMS-986393 plus one of these treatments:
- Alnuctamab, which boosts the body’s natural defenses to fight cancer. It is given by injection under the skin.
- Mezigdomide, which attaches to a protein called cereblon to help cause cancer cells to die. It is taken orally (by mouth).
- Iberdomide, which also attaches to cereblon and is taken orally.
Who Can Join
To join this study, there are a few conditions. You must:
- Have multiple myeloma that came back or keeps growing even after treatment.
- Have recovered from the serious side effects of prior therapies before getting the study treatment.
- Be well enough to walk and take care of yourself. You must be able to do activities such as office work or light housework.
- Be age 18 or older.
Contact
For more information and to see if you can join this study, please call Dr. Sham Mailankody’s office at 646-608-2091.