A Phase 2 Study of Erdafitinib for Progressive Brain Cancers With a Gene Fusion

Full Title

Purpose

Researchers are assessing how well erdafitinib works to treat gliomas that keep growing after treatment. The people in this study have glioma with a normal IDH gene and a fusion of two other genes (FGFR-TACC).

Erdafitinib blocks the action of the abnormal FGFR protein, which tells tumor cells to multiply. Giving erdafitinib may help to slow or shrink glioma growth in people with the FGFR-TACC gene fusion. Erdafitinib is taken orally (by mouth).

Who Can Join

To join this study, there are a few conditions. You must:

• Have a glioma that keeps growing after treatment and has normal IDH and an FGFR-TACC gene fusion.
• Have recovered from the serious side effects of prior therapies before taking erdafitinib.
• Be able to walk and do routine activities for more than half the time you are awake.
• Be age 18 or older.

Contact

For more information or to see if you can join this study, please call 212-610-0261. You may also call Dr. Thomas Kaley’s office at 212-639-5122.