Full Title
A Phase 1 Study of MOMA-313 Given as Monotherapy or in Combination With a PARP Inhibitor in Participants With Advanced or Metastatic Solid TumorsPurpose
Researchers want to find the best doses of MOMA-313 alone and with olaparib in people with cancer. The people in this study have advanced castration-resistant prostate cancer (CRPC) or pancreatic cancer. CRPC is prostate cancer that has spread and keeps growing even in the absence of hormones. Their cancers also have a genetic change called HR deficiency.
MOMA-313 and olaparib are each taken orally (by mouth). If you join this study, you will take MOMA-313 alone or with olaparib.
Who Can Join
To join this study, there are a few conditions. You must:
- Have HR-deficient CRPC or pancreatic cancer that has spread to other parts of the body.
- Have recovered from the serious side effects of previous treatments before taking the study therapy.
- Be able to walk and do routine activities for more than half the time you are awake.
- Be age 18 or older.
Contact
For more information or to see if you can join this study, please call Dr. Wassim Abida’s office at 646-442-4633.
Protocol
24-345
Phase
Phase I (phase 1)
Disease Status
Newly Diagnosed & Relapsed/Refractory
Investigator
Co-Investigators
Diseases
ClinicalTrials.gov ID
NCT06545942