A Phase 1 Study of MOMA-313 Alone and With Olaparib in People With Advanced Prostate or Pancreatic Cancer

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Full Title

A Phase 1 Study of MOMA-313 Given as Monotherapy or in Combination With a PARP Inhibitor in Participants With Advanced or Metastatic Solid Tumors

Purpose

Researchers want to find the best doses of MOMA-313 alone and with olaparib in people with cancer. The people in this study have advanced castration-resistant prostate cancer (CRPC) or pancreatic cancer. CRPC is prostate cancer that has spread and keeps growing even in the absence of hormones. Their cancers also have a genetic change called HR deficiency.

MOMA-313 and olaparib are each taken orally (by mouth). If you join this study, you will take MOMA-313 alone or with olaparib.

Who Can Join

To join this study, there are a few conditions. You must:

  • Have HR-deficient CRPC or pancreatic cancer that has spread to other parts of the body.
  • Have recovered from the serious side effects of previous treatments before taking the study therapy.
  • Be able to walk and do routine activities for more than half the time you are awake.
  • Be age 18 or older.

Contact

For more information or to see if you can join this study, please call Dr. Wassim Abida’s office at 646-442-4633.

Protocol

24-345

Phase

Phase I (phase 1)

Disease Status

Newly Diagnosed & Relapsed/Refractory

Investigator

Co-Investigators

ClinicalTrials.gov ID

NCT06545942