Dendritic cells are critical orchestrators of immune responses and represent a key therapeutic target in autoimmunity and cancer. Using single-cell approaches to elucidate dendritic cell heterogeneity, we have identified novel subsets, conserved across mouse and human, with divergent functional phenotypes. My work addresses the environmental cues that shape lineage specification and the functional role of dendritic cell subsets in tissue homeostasis and disease.
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