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MSK Researchers Identify First Evidence of Epigenetic Role in Breast Cancer
Researchers at Memorial Sloan Kettering Cancer Center have identified, for the first time, an epigenetic mechanism promoting breast cancer. The team found that inhibition of the PI3K pathway leads to activation of ER-dependent transcription through the epigenetic regulator KMT2D. These findings provide a rationale for epigenetic therapy in patients with PIK3CA-mutant, ER-positive breast cancer. While epigenetic factors have been known to play an important role in various cancers such as leukemia and lymphoma, this is the first evidence found in breast cancer. This research co-led by José Baselga, MD, PhD, Physician-in-Chief and Chief Medical Officer, appears in the March 24, 2017 issue of Science. For more information on this work and to speak with the study authors, contact [email protected].
In the Clinic
Surgeon in scrubs operating on patient.
Study Findings Could Help Women Make Decisions about Breast Cancer Surgery
Women who have reconstructive surgery after mastectomy and radiation for breast cancer are usually more satisfied with the results when their own tissue is used instead of implants.
Finding
Pictured: Kenneth Offit
New Findings May Lead to Better Predictions of Breast Cancer Risk in Women with Inherited Mutations
A study identifies genetic variations that alter the risk of breast cancer in women who have a certain gene mutation.
Finding
What Causes Leukemia after Breast Cancer? Research Shows That a Mutation May Be Present All Along
A study from MSK takes a deeper look at some of the causes of secondary leukemia.
Q&A
Female instructor leading a “chair yoga” class with female patients seated with back to camera and arms stretched to side.
Q & A: Which Complementary Therapies Work Best for Women With Breast Cancer?
Integrative medicine specialists determine which complementary therapies appear to be most effective.
In the Clinic
blood tube laying atop DNA sequence
Liquid Biopsy Can Guide Treatment for Women with Metastatic Breast Cancer
By identifying mutations found in a person’s cancer, this blood test can help doctors tailor treatments to those most likely to benefit.
In the Lab
Stem cells induced to become cardiomyocytes
Stem Cell Research Probes Why a Breast Cancer Treatment Sometimes Damages the Heart
Investigators are looking at how and why the breast cancer drug trastuzumab sometimes causes long-lasting and potentially serious cardiac side effects.
Hands on keyboard
New Tool to Predict Breast Cancer Metastasis
Memorial Sloan Kettering Cancer Center researchers have identified a feature in the DNA of breast cancer cells that might indicate the likelihood a woman's disease will become life threatening.
Finding
Colored dots (cells) separating through a funnel-like structure.
Large Study Pinpoints Genetic Changes Underlying Drug Resistance in the Most Common Type of Breast Cancer
Scientists are learning how estrogen receptor-positive breast cancer evolves to thwart hormonal therapies and are developing ways to stop it.
In the Clinic
Medical oncologist and breast cancer doctor Tiffany Traina
Can Women with Early-Stage Breast Cancer Safely Avoid Chemotherapy?
A new study suggests that many women with early-stage breast cancer receiving chemotherapy to prevent recurrence do not need it. Here, we look at the evidence.