In a proof-of-concept study, researchers at Memorial Sloan Kettering Cancer Center (MSK) and the National Institutes of Health (NIH) have developed an artificial intelligence (AI) tool that uses routine clinical data, such as that from a simple blood test, to predict whether someone’s cancer will respond to immune checkpoint inhibitors, a type of immunotherapy drug that helps immune cells kill cancer cells. The machine-learning model may help doctors determine if immunotherapy drugs are effective for treating a patient’s cancer.
The study, published June 3, 2024, in Nature Cancer, was led by researchers at the National Cancer Institute’s (NCI) Center for Cancer Research and MSK. NCI is part of the National Institutes of Health.
Currently, two predictive biomarkers are approved by the Food and Drug Administration for use in identifying patients who may be candidates for treatment with immune checkpoint inhibitors. The first is tumor mutational burden, which is the number of mutations in the DNA of cancer cells. The second is PD-L1, a tumor cell protein that limits the immune response and is a target of some immune checkpoint inhibitors. However, these biomarkers do not always accurately predict response to immune checkpoint inhibitors. Recent machine-leaning models that use molecular sequencing data have shown value in predicting response, but this kind of data is expensive to obtain and not routinely collected.
“This was a very productive collaboration between our cancer biomarkers research team and the members of Dr. Eytan Ruppin’s cancer data science lab, who are computational modeling experts,” says co-senior author Luc Morris, MD, a surgeon and research lab director at MSK. “Working together, we were able to develop a new predictive model for immunotherapy response across many different cancer types using only six simple variables. In contrast to prior models, some of which are very complex, this model is very accessible to clinicians. We’re excited that this model, LORIS, will be able to improve clinical decision-making and better identify patients who are most likely to benefit from immunotherapy.”
The new study details a different kind of machine-learning model that makes predictions based on five clinical features that are routinely collected from patients: a patient’s age, cancer type, history of systemic therapy, blood albumin level, and blood neutrophil-to-lymphocyte ratio, a marker of inflammation. The model also considers tumor mutational burden, assessed through sequencing panels. The model was constructed and evaluated using data from multiple independent data sets that included 2,881 patients treated with immune checkpoint inhibitors across 18 solid tumor types.
The model accurately predicted a patient’s likelihood of responding to an immune checkpoint inhibitor and how long they would live, both overall and before the disease returned. Notably, the researchers said, the model was also able to identify patients with low tumor mutational burden who could still be treated effectively with immunotherapy.
The researchers noted that larger prospective studies are needed to further evaluate the AI model in clinical settings. They have made their AI model, called Logistic Regression-Based Immunotherapy-Response Score (LORIS), publicly available at https://loris.ccr.cancer.gov. The tool estimates the likelihood of a patient responding to immune checkpoint inhibitors based on data on the six variables described above.
The study was co-led by Dr. Morris and Eytan Ruppin, M.D., Ph.D., of NCI’s Center for Cancer Research. The work was spearheaded by Tiangen Chang, Ph.D., and Yingying Cao, Ph.D., of Dr. Ruppin’s group at NCI’s Center for Cancer Research, and medical student Hannah Sfreddo of the Morris Lab.
Article adapted from the NCI: NIH scientists develop AI tool to predict how cancer patients will respond to immunotherapy.