Description  

MDA231-LM2-4175 is a breast adenocarcinoma cell line established from the MDA231-TGL cell line after 3 passage in nude mice. It is a triple negative breast cancer (TNBC) cell line and a lung-selective metastatic derivative.  

This cell line is part of a panel of human breast cancer cell lines selected to metastasize to specific organs.  

Source 

This cell line was established from a 51-year-old female of Caucasian ethnicity and was derived from a metastatic site of pleural effusion.   

Lead Inventor 

Joan Massagué, PhD, Chief Scientific Officer, Director, Sloan Kettering Institute, and Laboratory Head, Cancer Biology & Genetics Program, MSK 

This cell line is jointly owned with MD Anderson and is available for licensing through an interinstitutional agreement. 

Key References 

• Minn A et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050) 518-524. (PubMed ID: 16049480) 

• Selicharova I et al. (2008) 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231. Oncology reports, 19(5), 1237-1244. (PubMed ID: 18424382) 

Cellosaurus code:  

• RRID: CVCL_5998