Description

SK-HEP-1 is an immortal, human hepatic adenocarcinoma cell line that grows in adherent culture. This cell line is capable of forming tumors in immunocompromised mice. SK-HEP-1 cells in culture have been shown to produce fibronectin and functionally active alpha-1 protease inhibitor. In addition, they constitutively produce Interleukin-1.

Source

This cell line was established in 1971 from the ascites fluids of a 52-year old Caucasian male with adenocarcinoma of the liver.

Inventors

• Germain Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering
• Jorgen Fogh, PhD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering

Key References

• Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
• Glasgow JE et al. (1984) Fibronectin synthesized by a human hepatoma cell line. Cancer Research 44: 3022-3028 (PubMed ID: 6327032)
• Wang L et al. (2012) A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Molecular Cancer Therapeutics 11: 864-872 (PubMed ID: 22351746)

Comments

An alternative hypothesis regarding the origin of the SK-HEP-1 cells was presented by Heffelfinger and colleagues, who claim that these cells do not display properties of hepatocytes and are of endothelial origin (PubMed ID: 1371504).

Licensing Information

This cell line may be licensed nonexclusively for research or commercial purposes.

• Express License:  For internal research purposes by a for-profit entity:  1) Fill out MSK’s ATCC Express License, see here for links to the online fillable ATCC Express License, as well as a PDF version.  2) After execution by MSK, you will receive a signed copy, and can then place your order with ATCC. For detailed guidance on how to fill out this webform, see here. Please note:  In order to streamline and expedite the licensing of select MSK cell lines, the terms of this non-exclusive license are non-negotiable. This license is only available for select cell lines, including this one. Once this license has been executed by MSK, you will receive a signed copy and payment instructions; all payments up to $10,000 must be made by credit card.
• Commercial License: Contact MSK’s Tangible Materials team at [email protected].

For non-licensing requests from academic-research institutions: Contact Frances Weis-Garcia, PhD, Associate Laboratory Member/Head, Antibody & Bioresource Core Facility, MSK, 646-888-2354, [email protected].