Human Oncology & Pathogenesis Program

The Adrienne Boire Lab

Adrienne A. Boire, MD, PhD

ScientifDirector, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

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Featured News

Finding

Scientists Jan Remsik, Adrienne Boire, and Jessica Wilcox in the lab

MSK Researchers Learn What’s Driving ‘Brain Fog’ in People with COVID-19

The presence of inflammatory molecules in the cerebrospinal fluid appears to be causing many of the neurologic effects seen in people with COVID-19.

In the Lab

Iron Fiends: Cancer Cells in Brain and Spinal Fluid Survive by Monopolizing a Nutrient

Researchers gain insight into leptomeningeal metastasis, a devastating complication of advanced cancer.

In the Lab

Inspired by a Patient, a Doctor Finds Answers for a Devastating Cancer Complication

Research is providing new clues about how cancer spreads to spinal fluid, a condition called leptomeningeal metastasis.

Publications Highlights

Wijetunga NA, Goglia AG, Weinhold N, Berger MF, Cislo M, Higginson DS, Chabot K, Osman AM, Schaff L, Pentsova E, Miller AM, Powell SN, Boire A, and JT Yang 2022 Dynamic Mutational Landscape of CSF Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases. Clin Cancer Res Nov 30;CCR-22-2434.

Umemura Y, Khan B, Weill BJ, Buthorn JJ, Skakodub A, Ridder AJ, Nevel KS, Sun Y, and A Boire 2022 Discordance between perceptions and experience of lumbar puncture: A prospective study. Neurol Clin Pract 12(5):344-351.

Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN and A Boire 2022 Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis. J Clin Oncol 40(33):3858-3867.

Remsik J, Chi Y, Tong X, Sener U, Derderian C, ParkA, Saadeh F, Bale T and A Boire2022 Leptomeningeal metastatic cells adopt two phenotypic states. Cancer Rep (Hoboken) 5(4):e1236.

Haddock S, Alban TJ, Turcan Ş, Husic H, Rosiek E, Ma X, Wang Y, Bale T, Desrichard A, Makarov V, Monette S, Wu W, Gardner R, Manova K, Boire A, Chan TA. 2022 Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells. Neoplasia 28:100790.

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People

Adrienne A. Boire, MD, PhD

ScientifDirector, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
PhD, Tufts University, Boston, MA
MD, University of Chicago, Chicago, IL

646-888-3861: Office Phone
View physician profile: Physician profile

Members

Ana Rita Lobato Cortesao Nobre
Postdoctoral Scholar

Sofia Piedrafita-Ortiz
MSK Bridge Program Scholar

Jan Remsik, PharmD, PhD — Jan Remsik
Senior Research Scientist

Xinran Tong
Weil Cornell Graduate Student

Jessica Wilcox
Assistant Attending Neurologist

Lab Alumni

Majdi Alghader
Senior Research Technician

Giscard Barbier
Administrative Assistant

Sara Haddock
Graduate Student, Cornell BCMB

Anestashia Melford
Administrative Assistant

Lab Affiliations

Achievements

2021 Geoffrey Beene Junior Faculty Chair
American Academy of Neurology Neuro Oncology Investigator Award (2020)
Pershing Square Sohn Prize (2019)
Pew Biomedical Scholar (2018)
Damon Runyon Clinical Investigator Award (2017)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

General Opportunities

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Get in Touch

646-888-3861

Office Phone
646-888-2733

Office Fax

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Adrienne A. Boire discloses the following relationships and financial interests:

Apellis Pharmaceuticals
Professional Services and Activities
Department of Defense/Congressionally Directed Medical Research Programs (CDMRP)
Professional Services and Activities (Uncompensated)

Society for Neuro-Oncology (SNO)
Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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