Memorial Hospital Research Laboratories

The Andrew Kung Lab

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Research

Andrew Kung
Andrew Kung, MD, PhD
Chair, Department of Pediatrics

The Kung Lab leverages patient-driven discovery to identify drivers and therapeutic vulnerabilities in pediatric and young adult cancers. The research infrastructure of the lab bridges the clinic, dry lab, and wet lab, with experimental data derived from model systems as well as in-human studies. We have developed a variety of experimental platforms to support the preclinical evaluation of promising agents including capabilities for in vitro drug screening, cell line development from patient tumor tissue, and in vivo testing in patient-derived xenograft (PDX) models. We have embraced computational biology approaches to predict genomically and non-genetically encoded tumor vulnerabilities, and utilize preclinical models to validate these therapeutic hypotheses.

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Featured News

MSK Kids 2023: Six Key Areas of Cancer Research and Clinical Advances
MSK Kids 2023: Six Key Areas of Cancer Research and Clinical Advances
Physicians and researchers at MSK Kids, Memorial Sloan Kettering Cancer Center’s dedicated pediatric cancer program, completed several groundbreaking research studies in 2023. These studies, which focused on pediatric disease mechanisms, paved the way to promising new therapeutic approaches for improving patient outcomes.

Publications Highlights

Shukla N, Levine MF, Gundem G, Domenico D, Spitzer B, Bouvier N, Arango-Ossa JE, Glodzik D, Medina-Martínez JS, Bhanot U, Gutiérrez-Abril J, Zhou Y, Fiala E, Stockfisch E, Li S, Rodriguez-Sanchez MI, O’Donohue T, Cobbs C, Roehrl MHA, Benhamida J, Iglesias Cardenas F, Ortiz M, Kinnaman M, Roberts S, Ladanyi M, Modak S, Farouk-Sait S, Slotkin E, Karajannis MA, Dela Cruz F, Glade Bender J, Zehir A, Viale A, Walsh MF, Kung AL, Papaemmanuil E. Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers. Nat Commun. 2022 May 18;13(1):2485. doi: 10.1038/s41467-022-30233-7. PMCID: PMC9117241.

O’Donohue TJ, Ibanez G, Ferreira Coutinho D, Mauguen A, Siddiquee A, Rosales N, Calder P, Ndengu A, You D, Long M, Roberts SS, Kung AL, Dela Cruz FS. Translational Strategies for Repotrectinib in Neuroblastoma. Mol Cancer Ther. 2021 Sep 4;. doi: 10.1158/1535-7163.MCT-21-0126. [Epub ahead of print]

Spitzer B, Dela Cruz FS, Ibanez Sanchez GD, Zhang Y, Xiao W, Benayed R, Markova A, Rodriguez-Sanchez MI, Bouvier N, Roshal M, Kung AL, Shukla N. ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML. Blood Adv. 2021 Apr 13;5(7):1899-1902. doi: 10.1182/bloodadvances.2020003699. PubMed Central PMCID: PMC8045514.

Slotkin EK, Diolaiti D, Shukla NN, Dela Cruz FS, Clark JJ, Gundem G, Yellapantula VD, Levine MF, You D, Ma P, Pachhal S, Ibanez Sanchez G, Benayed R, Jungbluth AA, Smyth LM, Mauguen A, Gushterova I, Ding H, Spraggon L, Darnell R, Califano A, Ladanyi M, Papaemmanuil E, Kung AL, Hyman DM, Roberts SS. Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer. Cancer Discov. 2019 May;9(5):605-616. doi: 10.1158/2159-8290.CD-18-0953. Epub 2019 Mar 15. PubMed Central PMCID: PMC6497560.

Slotkin EK, Bowman AS, Levine MF, Dela Cruz F, Coutinho DF, Sanchez GI, Rosales N, Modak S, Tap WD, Gounder MM, Thornton KA, Bouvier N, You D, Gundem G, Gerstle JT, Heaton TE, LaQuaglia MP, Wexler LH, Meyers PA, Kung AL, Papaemmanuil E, Zehir A, Ladanyi M, Shukla N. Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor. Mol Cancer Res. 2021 Jul;19(7):1146-1155. doi: 10.1158/1541-7786.MCR-20-0722. Epub 2021 Mar 22. PubMed Central PMCID: PMC8293793.

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People

Andrew Kung

Andrew Kung, MD, PhD

Chair, Department of Pediatrics

  • MD, Stanford University School of Medicine

Members

Filemon Dela Cruz
Filemon Dela Cruz

Preclinical and Lab Program Lead

Daoqi You
Daoqi You

PDX Program Lead

Emily Slotkin
Emily Slotkin

Assistant Attending, AYA Preclinical Lead

Glorymar Ibanez Sanchez
Glorymar Ibanez Sanchez

Research Lab Manager & Drug Screen Program Lead

Andoyo Ndengu
Andoyo Ndengu

Cell Line Generation Program Lead

Diego Ferreira Coutinho
Diego Ferreira Coutinho

Research Associate

Andrika Thomas
Andrika Thomas

PROXC PDX Consortium Program Manager

Paul Calder
Paul Calder

Drug Formulation & Lab Operations

Xinyi Wang
Xinyi Wang

Data Manager

Tara O'Donohue
Tara O'Donohue

Instructor, Clinical Translation Investigator

Kristina Guillan
Kristina Guillan

Sr Animal Technician

Nestor Rosales
Nestor Rosales

Research Assistant

Armaan Siddiquee
Armaan Siddiquee

Animal Technician

Katie Souto
Katie Souto

Animal Technician

Matthew Long
Matthew Long

Sr Research Technician

Jaclyn Rosenzweig
Jaclyn Rosenzweig

Clinical Fellow

Chelsey Burke
Chelsey Burke

Assistant Attending Pediatrician

Raina Fishkin
Raina Fishkin

Animal Technician

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

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