Human Oncology & Pathogenesis Program

The Ingo Mellinghoff Lab

Research

Memorial Sloan Kettering medical oncologist Ingo Mellinghoff
Ingo K. Mellinghoff, MD, FACP

Our laboratory focuses on the study of molecular pathways that regulate brain tumor growth. Our long-term goal is to develop therapeutic paradigms that target specific properties of primary brain tumors, including genetic alterations in cancer signaling pathways, unique aspects of brain tumor metabolism, or interactions of brain tumor cells with their brain microenvironment. Our studies in experimental brain tumor models are closely linked to the evaluation of novel agents in early-phase clinical trials.

The Ingo Mellinghoff Lab

Publications Highlights

Pourmaleki M, Jones CJ, Mellinghoff SD, Greenstein BD, Kumar P, Foronda M, Navarrete DA, Campos C, Roshal M, Schultz N, Shah SP, Schietinger A, Socci ND, Hollmann TJ, Dogan A, Mellinghoff IK. Multiplexed spatial profiling of Hodgkin Reed-Sternberg cell neighborhoods in classic Hodgkin lymphoma. Clin Cancer Res. 2024 Jul 1. doi: 10.1158/1078-0432.CCR-24-0942. Online ahead of print. PMID: 38949890. DOI: 10.1158/1078-0432.CCR-24-0942.

Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, Mendez J, Yust-Katz S, Welsh L, Mason WP, Ducray F, Umemura Y, Nabors B, Holdhoff M, Hottinger AF, Arakawa Y, Sepulveda JM, Wick W, Soffietti R, Perry JR, Giglio P, de la Fuente M, Maher EA, Schoenfeld S, Zhao D, Pandya SS, Steelman L, Hassan I, Wen PY, Cloughesy TF; INDIGO Trial Investigators. Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. N Engl J Med. 2023 Aug 17;389(7):589-601. doi: 10.1056/NEJMoa2304194. Epub 2023 Jun 4. PMID: 37272516. DOI: 10.1056/NEJMoa2304194.

Tang CP, Clark O, Ferrarone JR, Campos C, Lalani AS, Chodera JD, Intlekofer AM, Elemento O, Mellinghoff IK. GCN2 kinase activation by ATP-competitive kinase inhibitors. Nat Chem Biol. 2022 Feb;18(2):207-215. doi: 10.1038/s41589-021-00947-8. Epub 2021 Dec 23. PMID: 34949839. DOI: 10.1038/s41589-021-00947-8.

Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK. Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15. PMID: 28619981. DOI: 10.1158/2159-8290.CD-17-0613.

Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C, Tsoi J, Clark O, Oldrini B, Komisopoulou E, Kunii K, Pedraza A, Schalm S, Silverman L, Miller A, Wang F, Yang H, Chen Y, Kernytsky A, Rosenblum MK, Liu W, Biller SA, Su SM, Brennan CW, Chan TA, Graeber TG, Yen KE, Mellinghoff IK. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340(6132):626-30. doi: 10.1126/science.1236062. Epub 2013 Apr 4. PMID: 23558169. DOI: 10.1126/science.1236062.

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People

Memorial Sloan Kettering medical oncologist Ingo Mellinghoff

Ingo K. Mellinghoff, MD, FACP

  • Physician-scientist Ingo Mellinghoff studies signal transduction alterations in primary brain tumors.
  • MD, Technical University Munich (Germany)
646-888-2766
Office Phone
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Physician profile

Members

Carl Campos
Carl Campos

Lab Manager

Christian Grommes, MD
Christian Grommes

Associate Attending

Maya Graham
Maya Graham

Assistant Attending

Smrutiben Mehta
Smrutiben Mehta

Senior Research Assistant

Arianna Izawa-Ishiguro
Arianna Izawa-Ishiguro

Pharmacology PhD Graduate Student

Maryam Pourmaleki
Maryam Pourmaleki

Research Fellow

Annalisa V. Ferrotta

Graduate Student

Cinthia Garcia

Graduate Student

Meaghan Grogan

Research Technician

Bridget Holle

Research Technician

Shereeda Perez

Assistant to Chair

Timothy Pham

Research Technician

Lab Alumni
Alexandra  Miller
Alexandra Miller

Assistant Attending

Daniel Navarrete
Daniel Navarrete

Senior Research Assistant

Charli Hertz
Charli Hertz

Research Technician

Brian Greenstein

Research Technician 

Marlene Tartaro

Research Technician

Owen Clark
Owen Clark

Senior Research Scientist

Alex Lee
Alex Lee

Research Technician

Veronica Nagle
Veronica Nagle

Graduate Student

Colin Tang
Colin Tang

Graduate Student

Sarah Tang
Sarah Tang
Lab Affiliations

Achievements

  • Neuro-Oncology Scientific Award, American Academy of Neurology (2023)
  • Member, Association of American Physicians (2020)
  • Member, American Society of Clinical Investigation (2013)
  • Advanced Clinical Research Award, American Society of Clinical Oncology (2009)
  • Clinical Scientist Development Award, Doris Duke Charitable Foundation (2008)
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  • Translational Science Award, Sidney Kimmel Foundation (2008)
  • Distinguished Scientist, Sontag Foundation (2007)
  • Scholar, Forbeck Research Foundation (2005)
  • Young Investigator Award, American Society of Clinical Oncology (2003)

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Ingo K. Mellinghoff discloses the following relationships and financial interests:

  • Roche
    Professional Services and Activities
  • Servier
    Professional Services and Activities
  • Tango Therapeutics
    Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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