Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and poor prognosis.
Chernichenko N, Omelchenko T, Deborde S, Bakst RL, He S, Chen C-H, Gusain L, Vakiani E, Katabi N, Hall A, Wong RJ. Cdc42 mediates cancer cell chemotaxis in perineural invasion. Mol Cancer Res. 2020;18(6):913–925. PMCID: PMC7272295
Deborde S, Yu Y, Marcadis A, Chen CH, Fan N, Bakst RL, Wong RJ. An in vivo murine sciatic nerve model of perineural invasion. J Vis Exp. 2018;134:56857. PMCID: PMC5965264
Bakst RL, Xiong H, Chen CH, Deborde S, Lyubchik A, Zhou Y, He S, McNamara W, Lee SY, Olson OC, Leiner IM, Marcadis AR, Keith JW, Al-Ahmadie HA, Katabi N, Gil Z, Vakiani E, Joyce JA, Pamer E, Wong RJ. Inflammatory monocytes promote perineural invasion via CCL2-mediated recruitment and cathepsin B expression. Cancer Res. 2017;77(2):6400–6414. PMCID: PMC5831809
Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara WF, Chernichenko N, Lee SY, Barajas F, Chen CH, Bakst RL, Vakiani E, He S, Hall A, Wong RJ. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016;126(4):1538–1554. PMCID: PMC4811155
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Richard J. Wong discloses the following relationships and financial interests:
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