We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and post-transcriptional RNA maturation, processing and decay. We pursue biochemical approaches to reconstitute key intermediates or complexes in these pathways and combine them with single particle cryo-EM and x-ray crystallography in conjunction with genetics and biochemistry to elucidate structure/activity relationships.

Learn about our individual projects and specific areas of interest, or see our recent publications.

A full list of publications the lab can be found by clicking here: Lima Lab publications.

A full list of macromolecular structures from the lab can be found by clicking here: Lima Lab structures.