Fatty acid oxidation fuels natural killer cell responses against infection and cancer. Sheppard S, Srpan K, Lin W, Lee M, Delconte RB, Owyong M, Carmeliet P, Davis DM, Xavier JB, Hsu KC, Sun JC. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2319254121.
Cutting Edge: STAT4 Promotes Bhlhe40 Induction to Drive Protective IFN-γ from NK Cells during Viral Infection. Kim H, Abbasi A, Sharrock J, Santosa EK, Sheppard S, Lau CM, Edelson BT, Sun JC. J Immunol. 2023 Nov 15;211(10):1469-1474.
Control of nutrient uptake by IRF4 orchestrates innate immune memory. Santosa EK, Kim H, Rückert T, Le Luduec JB, Abbasi AJ, Wingert CK, Peters L, Frost JN, Hsu KC, Romagnani C, Sun JC. Nat Immunol. 2023 Oct;24(10):1685-1697.
Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. Cell Rep. 2021 Jun 1;35(9):109210.
Deconvoluting global cytokine signaling networks in natural killer cells. Wiedemann GM, Santosa EK, Grassmann S, Sheppard S, Le Luduec JB, Adams NM, Dang C, Hsu KC, *Sun JC, *Lau CM. Nat Immunol. 2021 May;22(5):627-638. *corresponding author
Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells. Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC. J Immunol. 2021 Feb 1;206(3):465-470.
Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O’Shea JJ, Sun JC. Cell Rep. 2020 Dec 15;33(11):108498.
Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses. Diaz-Salazar C, Sun JC. Cell Rep. 2020 Sep 22;32(12):108186.
Cutting Edge: STAT1-Mediated Epigenetic Control of Rsad2 Promotes Clonal Expansion of Antiviral NK Cells. Wiedemann GM, Geary CD, Lau CM, Sun JC. J Immunol. 2020 Jul 1;205(1):21-25.
Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection. Diaz-Salazar C, Bou-Puerto R, Mujal AM, Lau CM, von Hoesslin M, Zehn D, Sun JC. J Exp Med. 2020 Apr 6;217(4): pii: e20190549.
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, *Sun JC, *Glimcher LH. Nat Immunol. 2019 Jul;20(7):865-878. *corresponding author
Cytomegalovirus infection drives avidity selection of natural killer cells. Adams NM, Geary CD, Santosa EK, Lumaquin D, Le Luduec JB, Sottile R, van der Ploeg K, Hsu J, Whitlock BM, Jackson BT, Weizman OE, Huse M, Hsu KC, Sun JC. Immunity. 2019 Jun 18;50(6):1381-1390.
Epigenetic control of innate and adaptive immune memory. Lau CM, Adams NM, Geary CD, Weizman OE, Rapp M, Pritykin Y, Leslie CS, Sun JC. Nat Immunol. 2018 Sep;19(9):963-972.
Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection. Geary CD, Krishna C, Lau CM, Adams NM, Gearty SV, Pritykin Y, Thomsen AR, Leslie CS, Sun JC. Cell Rep. 2018 Aug 21;24(8):1949-1957.
Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Adams NM, Lau CM, Fan X, Rapp M, Geary CD, Weizman OE, Diaz-Salazar C, Sun JC. Immunity. 2018 Jun 19;48(6):1172-1182.e6.
Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells. Madera S, Geary CD, Lau CM, Pikovskaya O, Reiner SL, Sun JC. J Immunol. 2018 Mar 15;200(6):1977-1981.
Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Rapp M, Lau CM, Adams NM, Weizman OE, O’Sullivan TE, Geary CD, Sun JC. Sci Immunol. 2017 Dec 8;2(18). pii: eaan3796.
ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Weizman OE, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, Degli-Esposti MA, Leslie CS, *Sun JC, *O’Sullivan TE. Cell. 2017 Nov 2;171(4):795-808.e12. *corresponding author
Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge. Johnson LR, Weizman OE, Rapp M, Way SS, Sun JC. Cell Rep. 2016 Oct 11;17(3):636-644.
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. O’Sullivan TE, Rapp M, Fan X, Weizman OE, Bhardwaj P, Adams NM, Walzer T, Dannenberg AJ, Sun JC. Immunity. 2016 Aug 16;45(2):428-41.
Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. O’Sullivan TE, Geary CD, Weizman OE, Geiger TL, Rapp M, Dorn GW 2nd, Overholtzer M, Sun JC. Cell Rep. 2016 May 31;15(9):1910-9.
Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. Madera S, Rapp M, Firth MA, Beilke JN, Lanier LL, Sun JC. J Exp Med. 2016 Feb 8;213(2):225-33.
BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. O’Sullivan TE, Johnson LR, Kang HH, Sun JC. Immunity. 2015 Aug 18;43(2):331-42.
Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion. Madera S, Sun JC. J Immunol. 2015 Feb 15;194(4):1408-12.
The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells. Karo JM, Schatz DG, Sun JC. Cell. 2014 Sep 25;159(1):94-107.
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. Geiger TL, Abt MC, Gasteiger G, Firth MA, O’Connor MH, Geary CD, O’Sullivan TE, van den Brink MR, Pamer EG, Hanash AM, Sun JC. J Exp Med. 2014 Aug 25;211(9):1723-31.
The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection. Beaulieu AM, Zawislak CL, Nakayama T, Sun JC. Nat Immunol. 2014 Jun;15(6):546-53.
Nfil3-independent lineage maintenance and antiviral response of natural killer cells. Firth MA, Madera S, Beaulieu AM, Gasteiger G, Castillo EF, Schluns KS, Kubo M, Rothman PB, Vivier E, Sun JC. J Exp Med. 2013 Dec 16;210(13):2981-90.
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6967-72.
Reviews:
Metabolic programming of organ-specific natural killer cell responses. Delconte RB, Sun JC. Immunol Rev. 2024 May;323(1):8-18.
Cardinal features of immune memory in innate lymphocytes. Santosa EK, Sun JC. Nat Immunol. 2023 Nov;24(11):1803-1812.
Thanks for the NK cell memories. Grassmann S, Sun JC. Nat Immunol. 2022 Nov;23(11):1512-1514.
Epigenetic regulation of natural killer cell memory. Lau CM, Wiedemann GM, Sun JC. Immunol Rev. 2022 Jan;305(1):90-110.
Natural Killer Cells: From Innate to Adaptive Features. Mujal AM, Delconte RB, Sun JC. Annu Rev Immunol. 2021 Apr 26;39:417-447.
Virus-specific NK cell memory. Sheppard S, Sun JC. J Exp Med. 2021 Apr 5;218(4):e20201731.
Natural killer cell responses to emerging viruses of zoonotic origin. Diaz-Salazar C, Sun JC. Curr Opin Virol. 2020 Oct;44:97-111.
Clonal expansion of innate and adaptive lymphocytes. Adams NM, Grassmann S, Sun JC. Nat Rev Immunol. 2020 Nov;20(11):694-707.
Innate immunological memory: from plants to animals. Sharrock J, Sun JC. Curr Opin Immunol. 2020 Feb;62:69-78.
Spatial and temporal coordination of antiviral responses by group 1 ILCs. Adams NM, Sun JC. Immunol Rev. 2018 Nov;286(1):23-36.
The widening spectrum of immunological memory. Lau CM, Sun JC. Curr Opin Immunol. 2018 Oct;54:42-49.
Memory responses of innate lymphocytes and parallels with T cells. Rapp M, Wiedemann GM, Sun JC. Semin Immunopathol. 2018 Jul;40(4):343-355.
Innate Lymphoid Cell Immunometabolism. O’Sullivan TE, Sun JC. J Mol Biol. 2017 Nov 24;429(23):3577-3586.
Memory responses of natural killer cells. Geary CD, Sun JC. Semin Immunol. 2017 Jun;31:11-19.
NK Cell Responses Redefine Immunological Memory. Adams NM, O’Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. J Immunol. 2016 Oct 15;197(8):2963-2970.
Development and maturation of natural killer cells. Geiger TL, Sun JC. Curr Opin Immunol. 2016 Apr;39:82-9.
Natural Killer Cell Memory. O’Sullivan TE, Sun JC, Lanier LL. Immunity. 2015 Oct 20;43(4):634-45.
Molecular Programming of Immunological Memory in Natural Killer Cells. Beaulieu AM, Madera S, Sun JC. Adv Exp Med Biol. 2015;850:81-91.
Transcriptional Control of NK Cells. Sun JC. Curr Top Microbiol Immunol. 2016;395:1-36.
Novel molecular mechanism for generating NK-cell fitness and memory. Karo JM, Sun JC. Eur J Immunol. 2015 Jul;45(7):1906-15.
Generation of Natural Killer Cell Memory during Viral Infection. O’Sullivan TE, Sun JC. J Innate Immun. 2015;7(6):557-62.
MicroRNA function in NK-cell biology. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. Immunol Rev. 2013 May;253(1):40-52.
NK cell development, homeostasis and function: parallels with CD8⁺ T cells. Sun JC, Lanier LL. Nat Rev Immunol. 2011 Aug 26;11(10):645-57.
NK cells and immune “memory”. Sun JC, Lopez-Verges S, Kim CC, DeRisi JL, Lanier LL. J Immunol. 2011 Feb 15;186(4):1891-7.
Re-educating natural killer cells. Sun JC. J Exp Med. 2010 Sep 27;207(10):2049-52.