Welcome to the Akhmanova lab, where we study how cells penetrate and migrate through tissues in vivo. By combining cutting-edge live imaging, mechano-biological techniques, and theoretical modelling, we aim to uncover the secrets behind these intricate processes.
Fig.1 Research methodology and goals at a glance.
Fig.2 Lab’s research fucus: cell invasion controlled by surrounding tissue cells.
Akhmanova M.*, Emtenani S., Krueger D., Gyoergy A., Guarda M., Vlasov M., Vlasov F., Akopian A., Ratheesh A., De Renzis S., Siekhaus D.* (2022): Cell division in tissues enables macrophage infiltration // Science 376 (6591), pp.394-396. * Co-corresponding author
Fendrych M., Akhmanova M. *, Merrin J., Glanc M., Hagihara S., Takahashi K., Uchida N., Torii KU., Friml J. (2018) Rapid and reversible root growth inhibition by TIR1 auxin signaling// Nature Plants, Jul;4(7):453-459.
DOI: 10.1038/s41477-018-0190-1 * Conceived and performed mathematical modeling part of the study