The Maria Akhmanova Lab

Welcome to the Akhmanova lab, where we study how cells penetrate and migrate through tissues in vivo. By combining cutting-edge live imaging, mechano-biological techniques, and theoretical modelling, we aim to uncover the secrets behind these intricate processes.

Cell migration is fundamental for the development and maintenance of multicellular organisms. Migrating cells, such as tissue-resident macrophages during embryogenesis or immune cells during inflammation, must invade and move through confined spaces, which provide both a substrate and resistance to forward movement. The strategies which cells use to overcome obstacles inside tissues are still a mystery.

Our mission is to decode the chemical and physical properties of tissue cells that control invasion. Based on our previous findings, we believe that the timing and location of invasion are heavily influenced by dynamic changes in the surrounding tissue, such as cell divisions. How do migrating cells sense these transient changes? Which signals direct their movements towards the favourable path? 

To explore these questions, we harness advanced in vivo imaging techniques, genetics, optogenetics, mechanical measurements, and computational modelling, primarily using Drosophila and tissue organoids as our experimental models.

Ultimately, we strive to reveal how cell-cell interactions in a dynamic multicellular environment drive the spread of migratory cells. This knowledge could illuminate complex phenomena like morphogenesis, immune cell infiltration into tumors, cancer metastasis, and tissue aging. By expanding our understanding, we hope to pioneer new approaches to manipulate cell invasion and infiltration, paving the way for innovative disease treatments.