Yinwen Liang

Lab Phone

212-639-3980

Email

[email protected]

Education and Training

Feb 2021-Present
Research associate, SKI Developmental Biology Program, The Joyner Lab

June 2016-Feb 2021
Research Fellow, SKI Developmental Biology Program, The Kathryn Anderson Lab

September 2009-June 2014
PhD in Cell Biology, Tsinghua University, CHINA

Research Interests

Primary cilia are microtubule-based organelles that extend from the surface of most vertebrate cells. Numerous genetic studies revealed that Hedgehog (HH) signaling in mammals depends on this organelle. Aberrant cilia formation and HH signaling causes human tumors and a wide spectrum of human inherited syndromes termed ciliopathies. Using mouse embryo as a model system, my research previously in Anderson lab and now in Joyner Lab aims to investigate the mechanisms that link HH signaling to the primary cilium and that control cilia formation during early embryo development.

Publications

Agbu, S.O., Liang, Y., Liu, A., Anderson, K.V. (2018) The small GTPase RSG1 controls a final step in primary cilia initiation. J Cell Biol. 217: 413-427. (Co-first author)

Liang, Y., Zhu, X., Wu, Q., Pan, J. (2018) Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Curr Biol. 28(15):2429-2435.e3.

Liang, Y., Dan, M., Pan, J. (2016) Mechanism of ciliary disassembly. Cellular and Molecular Life Sciences. 73(9):1787-802. (Invited review).

Liang, Y., Pang, Y., Wu, Q., Hu, Z., Han, X., Xu, Y., Deng, H., Pan, J. (2014) FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. Developmental Cell. 30(5), 585–597. (Co-first author)

Eguether, T., Agustin, J., Keady, B., Jonassen, J., Liang, Y., Francis, R., Tobita, K., Johnson, C., Abdelhamed, Z., Lo, C., Pazour G.J. (2014) IFT27 Links BBSome to IFT for Maintenance of Ciliary Signaling Compartment. Developmental Cell. 2014, 31(3), 279–290.

Liang, Y., Pan, J. (2013) Regulation of flagellar biogenesis by a calcium dependent protein kinase in Chlamydomonas reinhardtii. PLoS One. 8(7): e69902.