A Phase 2 Study of Nab-sirolimus and Letrozole in People With Endometrial Cancer

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Full Title

A Phase 2 Multi-center Open-label Trial of nab-Sirolimus in Combination with Letrozole in Advanced or Recurrent Endometrioid Endometrial Cancer

Purpose

Researchers want to know if nab-sirolimus works well against endometrial cancer. The people in this study have endometrial cancer that has spread or came back after treatment.

Nab-sirolimus is a drug called a kinase inhibitor. Kinases are proteins that cancer cells need to survive and grow. By blocking these proteins, nab-sirolimus may help slow or stop the growth of your cancer.

If you join this study, you will get nab-sirolimus plus letrozole. Letrozole is a standard treatment for endometrial cancer. Nab-sirolimus is given intravenously (by vein) and letrozole is taken orally (my mouth).

Who Can Join

To join this study, there are a few conditions. You must:

  • Have endometrial cancer that spread or came back after treatment.
  • Have recovered from the serious side effects of prior cancer therapies before getting the study treatment.
  • Be well enough to walk and take care of yourself. You must be able to do activities such as office work or light housework.
  • Be age 18 or older.

Contact

For more information and to see if you can join this study, please call Dr. Angela Green’s office at 646-888-6792.

Protocol

24-041

Phase

Phase II (phase 2)

Disease Status

Relapsed or Refractory

Investigator

Co-Investigators

ClinicalTrials.gov ID

NCT05997017