Full Title
A Phase 1/2, Open-Label Study to Investigate the Safety and Efficacy of Membrane Bound IL-15 Expressing Tumor-Infiltrating Lymphocytes (OBX-115) In Participants with Advanced Solid TumorsPurpose
The purpose of this study is to assess OBX-115 cellular therapy for people with advanced melanoma or lung cancer. The people in this study have melanoma or non-small cell lung cancer (NSCLC). Their cancers have metastasized (spread) or are inoperable (cannot be taken out with surgery) and keep growing even after treatment.
OBX-115 is a personalized cellular therapy that will be made specifically for each participant. It is a form of tumor-infiltrating lymphocyte (TIL) therapy. We will collect a sample of cells from your tumor and send it to a laboratory. There the cells will be genetically modified (changed) to make OBX-115. This treatment is designed to activate and train your immune system to find and kill cancer cells.
Acetazolamide is a drug that can enter cells easily because of its small size. Giving acetazolamide with OBX-115 may help OBX-115 find and kill cancer cells. OBX-115 is given intravenously (by vein) and acetazolamide is taken orally (by mouth).
Who Can Join
To join this study, there are a few conditions. You must:
- Have metastatic or inoperable melanoma or NSCLC that keeps growing after treatment.
- Have had prior treatment with immunotherapy medication.
- Be willing to relocate to the New York City area for the study therapy.
- Have recovered from the serious side effects of prior therapies before getting the study treatment.
- Be well enough to walk and take care of yourself. You must be able to do activities such as office work or light housework.
- Be age 18 or older.
Contact
For more information and to see if you can join this study, please call Dr. Alexander Shoushtari’s office at 646-888-4161.