Ivan Maillard, MD, PhD
Leukemia Specialist
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About Me
- Attending Physician
- Head of the Division of Hematologic Malignancies
I am a hematologist-oncologist and physician-scientist who specializes in treating people with blood cancers and blood disorders. This includes different types of leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN).
I am also the head of the Division of Hematologic Malignancies within the Department of Medicine at Memorial Sloan Kettering Cancer Center. As leader of this Division, my goal is to be an ally and supporter to all faculty members. I see my role as a matchmaker who identifies new partnerships and collaborations that can help maximize everyone’s potential so we can work together to deliver the best care for patients.
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I grew up in Switzerland and my early education was focused on music, literature, and the humanities. I was also interested in science, and I was motivated to become a physician because of the intersection between the human and scientific components of medicine. As a PhD student, I became passionate about scientific investigations to understand the role of the immune system in disease. As a resident, I had the privilege to care for people diagnosed with cancer, and I knew that this is something I wanted to pursue as a life-long career.
My training in medicine and the humanities helps me better identify the needs of each patient and come up with a plan for how to best meet these needs. Trying to find the most appropriate or innovative treatment is just one aspect of it. I also work to understand each person’s values and needs beyond their cancer diagnosis. No two patients are the same, even if they have the exact same diagnosis. I enjoy the challenge of figuring out how to take care of the person, not just the disease.
As a physician, my goal is to always offer the most advanced and latest treatment options to patients. I aim to be approachable and explain the diagnosis and treatment plan in a clear, understandable way. I also enjoy teaching. A part of my job involves training residents and fellows about the different aspects of clinical management and the scientific aspects of the diseases that we are treating.
My research has involved studying how blood cells are formed and how this process can go wrong in diseases such as cancer. I also examine bone marrow transplants and how the immune system reacts to them. A big part of my research has involved understanding how a specific signaling pathway, called Notch, affects the development and function of T cells, a type of immune cell. This research helps understand graft-versus-host disease (GVHD), a complication that can occur after a bone marrow or stem cell transplant in which donor immune cells identify the host’s tissue as foreign and attack it.
When I am not working, I love to travel and discover new countries and cultures with my wife, who is also a physician, and two daughters. We are a multicultural and multilingual family who speaks English, French, and Portuguese. As a musician, I am very interested in the arts and enjoy theater. We also love nature and enjoy hiking and being outdoors.
A leukemia specialist is a doctor with special training in diagnosing and treating leukemia.
My Specialties
- Internal Medicine
- Hematology
- Bone Marrow Transplant
- Leukemia
- Myelodysplastic Syndrome (MDS)
- Myeloproliferative Neoplasms (MPN)
Education
- BA, Gymnase de Chamblandes, Switzerland
- MD, University of Lausanne, Switzerland
- PhD, University of Lausanne, Switzerland
Residencies
- Internal Medicine, University of Lausanne, Switzerland
Awards and Honors
- Member, Association of American Physicians (2024)
- Interurban Clinical Club (2019)
- League of Research Excellence, University of Michigan Medical School (2014)
- DuPont Guerry, IV, MD Award for Outstanding Mentorship, University of Pennsylvania Perelman School of Medicine
- Member, American Society of Clinical Investigation (2013)
Fellowships
- Hematology/Oncology, University of Pennsylvania
Board Certifications
- Internal Medicine
- Hematology
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Colleagues
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
Clinical Trials
Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Search clinical trialsResearch and Publications
- Zhang Y, Sandy AR, Wang J, Shan GT, Radojcic V, Tran I, Friedman A, Kato K, He S, Cui S, Hexner E, Frank D, Emerson SG, Pear WS, Maillard I. Notch signaling is a critical regulator of allogeneic CD4+ T cell responses mediating graft-versus-host disease. Blood, 117(1): 299-308, 2011. PMCID: PMC3037751
- Tran IT, Sandy AR, Carulli AJ, Ebens C, Chung J, Shan GT, Radojcic V, Friedman A, Gridley T, Shelton A, Reddy P, Samuelson LC, Yan M, Siebel CW, Maillard I. Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest, 123(4): 1590-1604, 2013. PMCID: PMC3613915
- Chung J, Ebens CE, Perkey E, Radojcic V, Koch U, (…), Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest, 127(4): 1574-88, 2017. PMCID: PMC5373885
- Gómez Atria D*, Gaudette BT*, Londregan J*, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel CW, Ryan RJH, Robertson TF, Burkhardt JK, Pear WS, Allman D**, Maillard I**. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naïve B cells. J Clin Invest, 2022 Jul 1;132(13):e158885. doi: 10.1172/JCI158885. PMCID: PMC9246379.
- Tkachev V*, Vanderbeck A*, Perkey E*, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Burbach B, Shimizu Y, Panoskaltsis-Mortari, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS**, Maillard I**. Notch signaling drives intestinal graft-versus-host disease in mice and non-human primates. Science Translational Medicine15(702):eadd175, 2023. PMID: 37379368.
Visit PubMed for a full listing of Dr. Maillard’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.
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