Bao He Wan

Purported Benefits, Side Effects & More

Bao He Wan

Purported Benefits, Side Effects & More
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Common Names

  • Baohe pill
  • BaoHeWan teapills
  • Preserve Harmony Formula
  • Citrus and Crataegus Formula

For Patients & Caregivers

Tell your healthcare providers about any dietary supplements you’re taking, such as herbs, vitamins, minerals, and natural or home remedies. This will help them manage your care and keep you safe.


What is it?

Bao He Wan is a traditional Chinese medicine (TCM) formula. It’s made up of 8 different herbs. 

What are the potential uses and benefits?

Bao He Wan is used to treat:

  • Indigestion
  • Nausea (feeling like you’re going to throw up)
  • Vomiting (throwing up)
  • Diarrhea (loose or watery bowel movements).
  • Constipation (difficult or infrequent bowel movements)
  • Acid reflux
  • Abdominal pain
  • Bloating

Talk with your healthcare providers before taking herbal formulas. They can interact with some medications and affect how they work. For more information, read the “What else do I need to know?” section below.

What are the side effects?

Side effects have not been reported.

What else do I need to know?
  • Talk with your healthcare provider if you’re pregnant. BHW may not be safe for you.
  • Talk with your healthcare provider if you have gluten allergy. BHW contains wheat and barley sprouts.

For Healthcare Professionals

Clinical Summary

A traditional Chinese medicine (TCM) formula, Bao He Wan (BHW) has a long history of use for improving digestion. Documented in Tanxi Xinfa, it comprises eight herbs: Shan Zha (Chinese Hawthorn fruit), Shen Qu (Medicated leaven), Lai Fu Zi (Radish seed), Chen Pi (Aged Tangerine peel), Zhi Ban Xia (Prepared Pinellia Corm), Fu Ling (Poria mushroom), Lian Qiao (Forsythia fruit) and Mai Ya (Barley sprouts).                            

A large study found BHW  to be among the commonly prescribed herbal formulas for gastrointestinal disorders in post-surgery colon cancer patients (1).

In preclinical studies, the constituents of BHW were shown to promote gastric emptying, increase gastric acid secretion, and exert anti-ulcer effects  (2). In mice that were fed a high-protein and high-fat diet, BHW conferred anti-diarrheal effect by modulating the intestinal composition of lactase-producing bacteria  (3); by inhibiting the growth of conditionally pathogenic bacteria Ralstonia in the intestinal mucosa  (4); and by improving activities of various digestive enzymes including protease and amylase  (5). Furthermore, BHW was found to normalize enzymatic activity after cessation of diarrhea  (6).

BHW was also shown to reduce total cholesterol, low-density lipoprotein cholesterol and triglyceride levels in rats that were fed a high-fat diet by modulating bacterial composition  (7).

Clinical trials are needed to determine the efficacy of BHW against digestive issues.

Purported Uses and Benefits
  • Indigestion
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Acid reflux
  • Abdominal pain
  • Bloating
Contraindications
  • Do not take BHW if you are pregnant as it contains hawthorn.
  • Do not take BHW if you have gluten allergy because it contains wheat and barley sprouts (8).
Adverse Reactions

Side effects have not been reported.

Herb-Drug Interactions

None known.

Dosage (OneMSK Only)
References
  1. Chao TH, Fu PK, Chang CH, Chang SN, Chiahung Mao F, Lin CH. Prescription patterns of Chinese herbal products for post-surgery colon cancer patients in Taiwan. J Ethnopharmacol. Aug 8 2014;155(1):702-8. doi:10.1016/j.jep.2014.06.012
  2. He YS, Tan ZJ, Hui HY. Progress in baohe pill research. Chin Med J Res Prac. 2020;34:77-81.
  3. Zhou K, Deng N, Yi X, Cai Y, Peng M, Xiao N. Baohe pill decoction for diarrhea induced by high-fat and high-protein diet is associated with the structure of lactase-producing bacterial community. Front Cell Infect Microbiol. 2022;12:1004845. doi:10.3389/fcimb.2022.1004845
  4. Huang LL, Zheng T, Liu YW, Guo T, Tan ZJ. Diarrheal mice induced by a high-fat and high-protein diet could be cured by bohe pill regulating intestinal mucosal bacteria. J Food Nutr Res 2022;10:459–466.
  5. Guo K, Yan Y, Zeng C, Shen L, He Y, Tan Z. Study on Baohe Pills Regulating Intestinal Microecology and Treating Diarrhea of High-Fat and High-Protein Diet Mice. Biomed Res Int. 2022;2022:6891179. doi:10.1155/2022/6891179
  6. Shao HQ, He L, Xiao NQ, Xie GZ, Tan ZJ. Establishment of a mouse model of diarrhea with gastrointestinal food stagnation syndrome and the efficacy of baohe wan. Shih-chen Kuo I Kuo Yao. 2022;33:10-15.
  7. Li YB, Ma XL, Li ZG, Jia HH, Liang Y, Hao GM. Effects of baohe pills on blood lipid in SD rats with a high-fat diet on the basis of intestinal microbiota. World Chin Med. 2018;13:2107–2110+2116.
  8. AHPA. GUIDANCE: Compliance with the Food Allergen Labeling and Consumer Protection Act for Marketers of Chinese Herbal Products. July 2021. Available at https://www.ahpa.org/Files/Document%20Library/AHPA%20Guidance%20Documents/2021_AHPA_Guidance_FALCPA_for_TCM_Final.pdf. Last accessed March 5, 2025.
Email your questions and comments to aboutherbs@mskcc.org.

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