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445 News Items found
In the Clinic
Nancy Schroeder and her husband Mark
New Checkpoint Inhibitor Immunotherapy Treatment for Advanced Melanoma Shows Promise

Results from a phase 2 clinical trial report a combination of two checkpoint inhibitor immunotherapy drugs given before melanoma surgery prevents this aggressive skin cancer from coming back. This new drug combination also has fewer side effects than other immunotherapy treatments.
In the Lab
DNA winding around histones
Research Clarifies How IDH Mutations Cause Cancer

The MSK team’s goal was to get at the underlying defects in cells that these mutations cause.
Learning Curve
Pictured: Barbara Raphael & Chioma Enweasor
Summer Fellowship Gives Medical Students the Tools to Become Physician-Scientists

Our summer fellowship program helps medical students learn to become physician-scientists. Read about one of our trainees who investigated an imaging tool for use in patients with a rare uterine cancer.
In the Lab
Pictured: Daniel Thorek & Jan Grimm
Faster than the Speed of Light: New Imaging Approach Could Measure Tumor Activity

A new imaging approach being investigated by Memorial Sloan Kettering researchers could provide better information about a tumor’s molecular activity, allowing for a more accurate diagnosis.
Alexandra Joyner, Ming Li, and Kenneth Offit
Three Memorial Sloan Kettering Cancer Center Faculty Members Elected as 2021 AAAS Fellows

Three faculty members from Memorial Sloan Kettering Cancer Center (MSK) and Sloan Kettering Institute (SKI) have been elected to the 2021 class of American Association for the Advancement of Science (AAAS) Fellows.
In the Lab
Mouse glioblastoma tumor with phagocytic macrophages
Immune Cells in the Brain Could be Enlisted to Fight Glioblastoma

Memorial Sloan Kettering researchers say a drug that acts on noncancerous, tumor-infiltrating cells might provide a new treatment option for the most common and aggressive type of brain cancer.
Finding
Pedram Razavi, Jorge Reis-Filho, and Bob Li
Many Mutations Detected in Liquid Biopsy Tests Do Not Come from Cancer Cells, an MSK Study Finds

The new findings suggest the need for caution when interpreting the results from these tests.
Sloan Kettering Institute Researchers Look Beyond DNA to Identify Cancer Drivers

Researchers at the Sloan Kettering Institute have found that changes in an information-carrying molecule called messenger RNA (mRNA) can inactivate the functions of tumor suppressor genes and thereby promote cancer. The findings pinpoint previously unknown drivers of the disease, indicating that cancer diagnostics need to go beyond the analysis of DNA mutations.
In the Lab
An illustration of proteins serving as bar-code-reading drones
“Molecular Origami” Enables Proteins to Serve as Specialized Delivery Vehicles, Study Finds

Scientists at the Sloan Kettering Institute have identified a fundamentally new type of protein-sorting system in cells.
In the Lab
Immune cells surrounding a cancer cell
Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.