Andrew McPherson

Assistant Attending, Computational Oncologist

Andrew McPherson

Assistant Attending, Computational Oncologist
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Andrew McPherson

Office Phone

646-608-7558

Andrew McPherson is an Assistant Attending Computational Oncologist in the Department of Epidemiology and Biostatistics and a faculty member of Computational Oncology. Andrew’s research focuses on computational methods for analysis of single cell genomic data, with specific focus on understanding genomic instability, mutational processes, clonal evolution and the role of the microenvironment in cancer development and progression.  During his doctoral research, Dr. McPherson developed methods for cancer genome sequence analysis, including detection and characterization of genome rearrangements, and inference of clonal phylogenies.  Dr. McPhersons post-doctoral research at University of British Columbia focused on the development of computational methods and infrastructure for a novel single cell whole genome sequencing (scWGS) platform, Direct Library Preparation.  During his time at MSKCC, Dr. McPherson has led efforts to establish a production implementation of scWGS via DLP within MSKCC, and support use of the platform through collaborations with investigators throughout the institute. In addition, Dr. McPherson has contributed to several large scale single cell genomics studies of Breast and Ovarian cancer.

Publications

  1. Ceglia, N., Sethna, Z., Freeman, S., … McPherson, A. GeneVector: Identification of transcriptional programs using dense vector representations defined by mutual information. Nature Communications (2023, Accepted).
  2. Funnell, T., O’Flanagan, C.H., Williams, M.J. McPherson, A.W. et al.Single-cell genomic variation induced by mutational processes in cancer Nature (2022) Oct 26 PMCID: PMC9712114
  3. Vázquez-García, I., Uhlitz, F., Ceglia, N. … McPherson, A, Weigelt, B, Zamarin, D, Shah, S.P. . Ovarian cancer mutational processes drive site-specific immune evasion Nature 612, 778–786 (2022). PMCID: PMC9771812 PMCID: PMC8396073
  4. Salehi S, Kabeer F, Ceglia N, Andronescu M, Williams MJ, et al., McPherson A, Bouchard-Côté A, Aparicio S, Shah SP. Clonal fitness inferred from time-series modelling of single-cell cancer genomes. Nature. 2021;595(7868):585-90. PMCID: PMC8396073
  5. Zhang AW, McPherson A, et al. Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer. Cell. 2018 Jun 14;173(7):1755-1769.e22. doi: 10.1016/j.cell.2018.03.073. Epub 2018 May 10. PubMed PMID: 29754820.
  6. McPherson AW, et al. ReMixT: clone-specific genomic structure estimation in cancer. Genome Biol. 2017 Jul 27;18(1):140. doi: 10.1186/s13059-017-1267-2. Erratum in: Genome Biol. 2017 Oct 6;18(1):188. PubMed PMID: 28750660; PubMed Central PMCID: PMC5530528.
  7. McPherson A, et al. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer. Nat Genet. 2016 Jul;48(7):758-67. doi: 10.1038/ng.3573. Epub 2016 May 16. PubMed PMID: 27182968.

To view more publications, visit PubMed