Recent MSK Discoveries & Advances

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Recent MSK Discoveries & Advances

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Memorial Sloan Kettering researchers are relentlessly exploring every aspect of cancer — from basic investigations of cells and molecules to clinical trials of new treatments and population-wide studies of the disease. While our core mission is to translate this knowledge into new strategies to control cancer, many of our investigators are also making scientific progress against other diseases and conditions.

Below are some examples of discoveries and advances that recently were made in our laboratories and clinics, and featured in our news stories.

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377 News Items found
In the Lab
cartoon of man hitting a snooze button
Drug That Hits CAR T Snooze Button Can Quiet a Cytokine Storm

An FDA-approved drug used to treat leukemia can serve as a temporary off switch for CAR T cells, MSK scientists have found.
In the Lab
Fluorescent red and green cells
Scientists Use CRISPR to Learn How Cells Make Decisions

The genome-editing technique uncovered several genes previously not known to influence embryonic development.
In the Lab
DNA winding around histones
Research Clarifies How IDH Mutations Cause Cancer

The MSK team’s goal was to get at the underlying defects in cells that these mutations cause.
In the Lab
MSK cancer researchers Elizabeth Adams, Charles Sawyers, and Rohit Bose
Researchers Unravel the Biology of a Distinct Prostate Cancer Subtype

Mutations in a gene called FOXA1 are responsible for a distinct class of prostate cancer tumors, MSK researchers have found.
In the Lab
An illustration of a samurai and a crab.
Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice.
In the Lab
Immune cells surrounding a cancer cell
Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.
In the Lab
Two clusters of colored blobs with a diagram in the middle
Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.
Roundup
Crowd shot at ASCO 2019
Highlights from ASCO 2019: Progress in Treating Cancer in Children

MSK Kids doctors report advances in treating pediatric cancers at the 2019 meeting of the American Society of Clinical Oncology.
In the News
MSK medical oncologist Eileen O'Reilly with a patient
ASCO 2019: PARP Inhibitors Benefit People with Pancreatic Cancer Who Have a BRCA Mutation

Results from a large phase III clinical trial unveiled at this year’s ASCO meeting identify an effective targeted therapy for a subset of people with pancreatic cancer.
Q&A
Medical oncologist William Tap
What Can Be Learned from a Negative Clinical Trial? Findings from a Sarcoma Study at ASCO 2019

At the ASCO meeting in Chicago, MSK medical oncologist William Tap talked about disappointing results from a new sarcoma drug, which didn’t increase survival.