Adriana Haimovitz-Friedman, PhD

Attending Radiation Biologist

Adriana Haimovitz-Friedman, PhD

Attending Radiation Biologist
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Adriana Haimovitz-Friedman, PhD

Office Phone

646-888-2172

Office Fax

646-422-0281

Publications

Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Modulation of the Apoptotic Response: Potential for Improving the Outcome in Clinical Radiotherapy. Seminars in Radiation Oncology, 1996; 6:273-283.

Haimovitz-Friedman A. Radiation-induced Signal Transduction and Stress Response. In: Radiation Research special issue commemorating the discovery of radium and polonium by Marie Curie in 1898. Radiat. Res. 1998; 150: S102-S108.

Fuks Z, Persaud R, Alfieri A, McLoughlin M, Schwartz J L, Cordon-Cardo C, Seddon AP, Haimovitz-Friedman A. Basic Fibroblast Factor Protects Endothelial Cells Against Radiation-Induced Programmed Cell Death in vitro and in vivo. Cancer Res.1994; 54: 2582-2590.

Haimovitz-Friedman A, Balaban N, McLaughlin M, Ehleiter D, Michaeli J, Fuks Z. Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells Against Radiation-Induced Apoptosis. Cancer Res. 1994; 54: 2591-2597.

Haimovitz-Friedman A, Kan C-C, Ehleiter D, Persaud R, McLaughlin M, Fuks Z. Ionizing Radiation Acts Directly on Cellular Membranes to Generate Ceramide and Initiate Apoptosis. J. Exp. Med. 1994; 180:525-535.

Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Environmental stresses signal apoptosis through a ceramide-initiated SAPK/JNK-mediated cascade. Nature, 1996; 380:75-79.

Liao W C*, Haimovitz-Friedman A*, Persaud R, McLoughlin M, Ehleiter D, Zhang N, Gatei M, Lavin M, Kolesnick RN, Fuks Z. ATM inhibits DNA damage-induced apoptosis via ceramide synthase. J. Biol. Chem. 1999; 274: 17908-17917.
*Both authors contributed equally to this publication.

Garzotto M, Haimovitz-Friedman A, White-Jones M, Liao W-C, Huryk R, Heston DW, Cordon-Cardo C, Kolesnick RN, Fuks Z. Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Can. Res., 1999, 59: 5194-520.

Paris F, Kang A, Capodieci P, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Fuks Z, Kolesnick RN. Endothelial Apoptosis is the Primary Lesion Initiating Radiation Damage to the Intestines. Science, 2001 July 293: 293-297.

Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick RN. Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med., 8 : 901-902, 2002.

Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Tumor response to low-dose radiotherapy regulated by endothelial cell apoptosis. Science, 300: 1155-1159, 2003.

Truman J-P, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem 2005, 280: 23262-23272.

Chang H-J, Maj J, Paris FE, Xing HR, Zhang J, Truman J-P, Cordon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med., 2005, 11: 484-490.

Rotolo J, Maj J, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng E, Kolesnick R, Fuks Z. Bax and bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys., 2008, 70: 321-650.

Truman J-P, Rotenberg SA, Kang J-H, Lerman G, Fuks Z, Kolesnick R, and Haimovitz-Friedman A. PKCα activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biology and Therapy 2009: 8(1): 54-63.