Research Labs

Molecular biologist John Maciejowski studies the causes of complex chromosome rearrangements and the patterns of hypermutation that shape cancer genomes.

Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.

Molecular geneticist Elli Elli Papaemmanouil performs systematic interrogations of well-annotated clinical trial cohorts in leukemia and cancer to explore how the compound genetic and clonal architecture in patients' leukemias and tumors dictate clinical phenotype, disease progression, and clinical outcomes.

The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.

Cell biologist Meng-Fu Bryan Tsou studies cell cycle control of centrosome duplication and degeneration, as well as cilia assembly and disassembly.

The Tulpule lab studies how cells compartmentalize critical cellular processes with a focus on biomolecular condensates in cancer.