Research Labs

Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.

The Shah lab focuses on the major topics of cancer evolution, single cell genomics and transcriptomics, mutational processes and prediction of drug response.

My research has focused on the development of novel statistical and bioinformatic methodologies that facilitate the study of translational research questions in cancer genomics and immuno-oncology.

The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit.

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.

Physician-scientist Samuel Singer studies the genomic alterations that define new targets for therapy in sarcoma. I am a surgical oncologist who specializes in the diagnosis and treatment of soft tissue sarcoma. I have extensive experience with this group of cancers, and am one of just a few surgeons in the world focused solely on treating sarcoma patients. My years of experience have enabled me to devise surgical techniques that improve the ability to completely remove these tumors. In addition to my clinical sarcoma practice, I conduct laboratory research to develop new methods to improve the diagnosis and treatment of sarcoma. I lead both a National Cancer Institute Specialized Program in Research Excellence (SPORE) and the Sarcoma Genome Project.

The Smith Lab studies rectal cancer, and we developed the first patient-derived rectal cancer organoids. These rectal cancer organoids recapitulate the clinical and molecular features of patients with rectal cancer and uniquely reflect the clinical responses to therapy of the patients from which they were derived.

Interventional radiologist Constantinos Sofocleous leads research in the optimization of image-guided therapies for colorectal cancer metastases.

Computational biologist Ruslan Soldatov develops computational methods to study cell fate decisions and somatic evolution in normal tissues and cancer.