Research Labs

Computational biologist Dana Pe’er combines single-cell and spatial profiling technologies with machine learning approaches to address fundamental questions in gene regulation, cellular plasticity and cell-cell communication in the contexts of cancer, immunity and development.

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.

Pharmacologist Neal Rosen focuses on understanding biochemical mechanisms underlying phenotypes caused by tyrosine kinase activation in epithelial tumors and developing new therapeutic strategies.

Physician-scientist Charles Rudin focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models.

Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.

Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.