Read up on the latest publications in diversity-oriented synthesis, rational drug design, chemical biology, and drug discovery research from the Tan Lab!

Selected Publications: Text Only | Graphical Abstracts
Complete Publications: Text Only | Graphical Abstracts

Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.

73. Structural basis for transthiolation intermediates in the ubiquitin pathway.
    Kochańczyk, T.; Hann, Z. S.; Lux, M. C.; Delos Reyes, A. M. V.; Ji, C.; Tan, D. S.* ; Lima, C. D.* Nature 2024, 633, 216–223.
    [ Abstract | PubMed | PMC ]

62. Engineering CAR-T cells to activate small-molecule drugs in situ.
    Gardner, T. J.; Lee, J. P.; Bourne, C. M.; Wijewarnasuriya, D.; Kinarivala, N.; Kurtz, K. G.; Corless, B. C.; Dacek, M. M.; Chang, A. Y.; Mo, G.; Nguyen, K. M.; Brentjens, R. J.; Tan, D. S.*; Scheinberg, D. A*. Nat. Chem. Biol. 2022, 18, 216–225.
    [ Abstract | PubMed | PMC ]
    (Highlighted in Nat. Chem. Biol.)

61. Cheminformatic analysis of natural product-based drugs and chemical probes.
    Stone, S.; Newman, D. J.; Colletti, S. L.; Tan, D. S.* Nat. Prod. Rep. 2022, 39, 20–32.
    [ Abstract | PubMed | PMC ]

60. Defining new chemical space for drug penetration into Gram-negative bacteria.
    Zhao, S.; Adamiak, J. W.; Bonifay, V.; Mehla, J.; Zgurskaya, H. I.; Tan, D. S.* Nat Chem Biol 2020, 16, 1293–1302.
    [ Abstract | PubMed | PMC ]

54. Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
    Lux, M. C.; Standke, L. C.; Tan, D. S.* J. Antibiot. 2019, 72, 325–349.
    [ Abstract | PubMed | PMC ]

53. Structure-based design, synthesis, and biological evaluation of non-acyl sulfamate inhibitors of the adenylate-forming enzyme MenE.
    Evans, C. E.^†; Si, Y.^†; Matarlo, J. S.; Yin, Y.; French, J. B.; Tonge, P. J.*; Tan, D. S.* Biochemistry 2019, 58, 1918–1930.
    [ Abstract | PubMed | PMC ]

40. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
    Davis, T. D.; Gerry, C. J.; Tan, D. S.* ACS Chem. Biol. 2014, 9, 2535–2544.
    [ Abstract | PubMed | PMC ]
    (Highlighted in ACS Chem. Biol.)

36. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
    Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
    [ Abstract | PubMed | PMC ]

34. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    [ Abstract | PubMed | PMC ]
    (Highlighted in SciBX )

32. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
    Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
    [ Abstract | PubMed | PMC ]

28. Active site remodelling accompanies thioester bond formation in the SUMO E1.
    Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
    [ Abstract | PubMed | PMC ]
    (Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology )

27. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
    Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
    [ Abstract | PubMed | PMC ]
    (Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )