Hospital Research Teams

Advanced Computing and Oncology Lab

Overview

Tafadzwa Lawrence Chaunzwa
Lab Head

The Advanced Computing and Oncology Lab, led by physician-scientist, Dr. Tafadzwa L. Chaunzwa, is dedicated to advancing the intersection of clinical oncology and computational sciences, with a primary focus on lung cancer and related thoracic malignancies. With formal training and expertise as an engineer, data scientist, and oncologist, Dr. Chaunzwa brings a uniquely interdisciplinary approach to oncology research. His work leverages artificial intelligence (AI) and machine learning (ML) to analyze multimodal oncology data, uncovering novel insights into cancer pathogenesis, treatment response, toxicity, and prognosis, and developing advanced clinical prediction models to improve cancer care.

Housed at the Mortimer B. Zuckerman Research Center at Memorial Sloan Kettering Cancer Center’s main campus in Manhattan, the Advanced Computing and Oncology/Chaunzwa Lab is positioned at the cutting edge of AI and oncology research, with access to unparalleled resources, core facilities, and large-scale datasets at the world’s first and largest private cancer center. Our mission is to pioneer breakthroughs in cancer research and innovation, transforming cutting-edge AI technologies into real-world improvements in patient care.

Lab members at all levels - including undergraduate, medical, and graduate students, clinical residents, and fellows – work alongside data/computer scientists, engineers, postdoctoral fellows, and the principal investigator to collect data, analyze trends, and develop novel AI/ML prediction models for oncology applications. As part of MSK’s robust collaborative ecosystem, we contribute to a range of initiatives in cancer imaging, and advanced oncology data modeling, integrating radiology, digital pathology, genomics, circulating tumor markers, and patient-reported demographic data. We are part of the Imaging and Radiation Sciences Program at MSK and maintain close collaborative ties with world-leading experts in radiation and medical oncology, medical physics, radiology, thoracic surgery, and computational oncology.

By bridging scientific innovation with clinical relevance, our research aims to drive both methodological advancements in AI and scientific computing, as well as meaningful improvements in patient outcomes. The lab is generously supported by institutional and external grants.

Publications

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Abbosh C, Frankell AM, Harrison T, Kisistok J, Garnett A, Johnson L, Veeriah S, Moreau M, Chesh A, Chaunzwa TL, Weiss J, Schroeder MR, Ward S, Grigoriadis K, Shahpurwalla A, Litchfield K, Puttick C, Biswas D, Karasaki T, Black JRM, Martínez-Ruiz C, Bakir MA, Pich O, Watkins TBK, Lim EL, Huebner A, Moore DA, Godin-Heymann N, L’Hernault A, Bye H, Odell A, Roberts P, Gomes F, Patel AJ, Manzano E, Hiley CT, Carey N, Riley J, Cook DE, Hodgson D, Stetson D, Barrett JC, Kortlever RM, Evan GI, Hackshaw A, Daber RD, Shaw JA, Aerts HJWL, Licon A, Stahl J, Jamal-Hanjani M; TRACERx Consortium; Birkbak NJ, McGranahan N, Swanton C. Nature. 2023 Apr;616(7957):553-562. doi: 10.1038/s41586-023-05776-4. Epub 2023 Apr 13.

Foundation model for cancer imaging biomarkers.Pai S, Bontempi D, Hadzic I, Prudente V, Sokač M, Chaunzwa TL, Bernatz S, Hosny A, Mak RH, Birkbak NJ, Aerts HJWL. Nat Mach Intell. 2024;6(3):354-367. doi: 10.1038/s42256-024-00807-9. Epub 2024 Mar 15.

Body Composition in Advanced Non-Small Cell Lung Cancer Treated With Immunotherapy.Chaunzwa TL, Qian JM, Li Q, Ricciuti B, Nuernberg L, Johnson JW, Weiss J, Zhang Z, MacKay J, Kagiampakis I, Bikiel D, Di Federico A, Alessi JV, Mak RH, Jacob E, Awad MM, Aerts HJWL. JAMA Oncol. 2024 Jun 1;10(6):773-783. doi: 10.1001/jamaoncol.2024.1120.

Large language models to identify social determinants of health in electronic health records.Guevara M, Chen S, Thomas S, Chaunzwa TL, Franco I, Kann BH, Moningi S, Qian JM, Goldstein M, Harper S, Aerts HJWL, Catalano PJ, Savova GK, Mak RH, Bitterman DS. NPJ Digit Med. 2024 Jan 11;7(1):6. doi: 10.1038/s41746-023-00970-0.

Clinical Informatics Approaches to Understand and Address Cancer Disparities.Chaunzwa TL, Del Rey MQ, Bitterman DS. Yearb Med Inform. 2022 Aug;31(1):121-130. doi: 10.1055/s-0042-1742511. Epub 2022 Dec 4.

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People

Members

Biniam Garosma

Data Science, Research Assistant

Alexander Kim

University of Illinois Student

Ryan Kim

Student

Victor Lee

Yale Radiation Oncology Resident

Innocent Maturure

The College of St. Scholastica

Jason McFadden

Yale Medical Student

Jeff Meng

Postdoctoral Fellow, Computational Oncology; Resident Physician, Radiation Oncology

David Miller

Radiation Oncology Resident

Mariya Mushtaq

Computer Science Student

Ricardo Reyes

Harvard Medical Student

Elaine Yang

Yale Medical Student

Affiliations

Achievements

  • James D. Cox Research Award, Radiation Oncology Institute (2022)
  • Young Investigator Award, American Society of Clinical Oncology/Conquer Cancer Foundation (2023)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

We are looking for Post-Doctoral Fellows, Graduate Research Assistants, Data Analysts, and Student Researchers.

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