The Geoffrey Beene Cancer Research Center (GBCRC) annual retreats continue to promote a vibrant research community at Memorial Sloan Kettering Cancer Center by enhancing the collaboration among different departments across the institution. The agenda of the two-day retreat focuses on a wide array of innovative and groundbreaking translational research topics, which reflect the mission of the Geoffrey Beene Cancer Research Center. The retreats host about 250 attendees including lab members and senior leadership from the Sloan Kettering Institute’s Cancer Biology and Genetics Program (CBG), the Human Oncology and Pathogenesis Program (HOPP) within Memorial Hospital, and faculty members from across Memorial Sloan Kettering Cancer Center. Each year the faculty planning committee invites an external speaker to attend the 2-day event and interact with attendees and give a keynote talk. A cocktail hour and poster session include poster presentations from trainees across Memorial Sloan Kettering Cancer Center. Each year the GBCRC extends five poster awards to the presenters chosen by fellow trainees and faculty members. Because of the enthusiastic participation from faculty members and trainees across Memorial Sloan Kettering, the annual retreat continues to be the most successful event for the Geoffrey Beene Cancer Research Center. The event promotes the mission of the GBCRC by focusing on translational research in both the clinical and lab setting and by bringing together faculty members from across the institution and fostering a collaborative environment. We are grateful to the Geoffrey Beene Foundation for its continued support of both the Geoffrey Beene Cancer Research Center and the Annual Retreat.