Group Meeting Papers 2007

The Derek Tan Lab
Research Overview
Projects
Featured News
Publications
Open Positions
News Articles
Research Resources
Lab Photo Albums

Group Meeting Papers 2007

Share
Share

Here is a list of research papers that were presented for discussion in our 2007 weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.

3 Dec 2007, presented by Chris Stratton
Deconstructing fragment-based inhibitor discovery.
Babaoglu, K.; Shoichet, B. K.* Nat. Chem. Biol. 2006, 2, 720-723.
[ Abstract ]

27 Nov 2007, presented by Shalini Balakrishnan
N-Phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri.
Geske, G. D.; O’Neill, J. C.; Blackwell, H. E.* ACS Chem. Biol. 2007, 2, 315-319.
[ Abstract ]

19 Nov 2007, presented by Jackie Wurst
Copper-free click chemistry for dynamic in vivo imaging.
Baskin, J. M.; Prescher, J. A.; Laughlin, S. T.; Agard, N. J.; Chang, P. V.; Miller, I. A.; Lo, A.; Codelli, J. A.; Bertozzi, C. R.* Proc. Natl. Acad. Sci. USA 2007, 104, 16793-16797.
[ Abstract ]

5 Nov 2007, presented by Renato Bauer
Total synthesis of azadirachtin - Finally completed after 22 years.
Jauch, J.* Angew. Chem. Intl. Ed. 2007, 46, in press.
[ Abstract ]

29 Oct 2007, presented by Xuequan Lu
Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids.
Long, X.; Deng, S.; Mattner, J.; Zang, Z.; Zhou, D.; McNary, N.; Goff, R. D.; Teyton, L.; Bendelac, A.; Savage, P. B.* Nat. Chem. Biol. 2007, 3, 559-564.
[ Abstract ]

22 Oct 2007, presented by Felix Kopp
Contribution of a solute’s chiral solvent imprint to optical rotation.
Mukhopadhyay, P.; Zuber, G.; Wipf, P.; Beratan, D. N.* Angew. Chem. Intl. Ed. 2007, 46, 6450-6452.
[ Abstract ]

24 Sep 2007, presented by Justin Cisar
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina, A.; Vilenchik, M.; Moulick, K.; Aguirre, J.; Kim, J.; Chiang, A.; Litz, J.; Clement, C. C.; Kang, Y.; She, Y.; Wu, N.; Felts, S.; Wipf, P.; Massague, J.; Jiang, X.; Brodsky, J. L.; Krystal, G. W.; Chiosis, G.* Nat. Chem. Biol. 2007, 3, 498-507.
[ Abstract ]

18 Sep 2007, presented by Shiying Shang
Epoxide-opening cascades promoted by water.
Vilotijevic, I.; Jamison, T. F.* Science 2007, 317, 1189-1192.
[ Abstract ]

25 Jul 2007, presented by Xuequan Lu
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.
Rock, F. L.; Mao, W.; Yaremchuk, A.; Tukalo, M.; Crépin, T.; Zhou, H.; Zhang, Y.-K.; Hernandez, V.; Akama, T.; Baker, S. J.; Plattner, J. J.; Shapiro, L.; Martinis, S. A.; Benkovic, S. J.; Cusack, S.; Alley M. R. K.* Science 2007, 316, 1759-1761.
[ Abstract ]

2 Jul 2007, presented by Felix Kopp
Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator.
Tour, O.; Adams, S. R.; Kerr, R. A.; Meijer, R. M.; Sejnowski, T. J.; Tsien, R. W.; Tsien, R. Y.* Nat. Chem. Biol. 2007, 3, 423-431.
[ Abstract ]

18 Jun 2007, presented by Chris DiBlasi
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Armbruster, B. N.; Li, X.; Pausch, M. H.; Herlitze, S.; Roth, B. L.* Proc. Natl. Acad. Sci. USA 2007, 104, 5163-5168.
[ Abstract ]

11 Jun 2007, presented by Guodong Liu
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.
Khidekel, N.; Ficcaro, S. B.; Clark, P. M.; Bryan, M. C.; Swaney, D. L.; Rexach, J. E.; Sun, Y. E.; Coon, J. J.; Peters, E. C.; Hsieh-Wilson, L. C.* Nat. Chem. Biol. 2007, 3, 339-348.
[ Abstract ]

21 May 2007, presented by Justin Cisar
A semisynthetic epitope for kinase substrates.
Allen, J. J.; Li, M.; Brinkworth, C. S.; Paulson, J. L.; Wang, D.; Hübner, A.; Chou, W.-H.; Davis, R. J.; Burlingame, A. L.; Messing, R. O.; Katayama, C. D.; Hedrick, S. M.; Shokat, K. M.* Nat. Methods 2007, 4, 511-516.
[ Abstract ]

15 May 2007, presented by Shiying Shang
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
Belenky, P.; Racette, F. G.; Bogan, K. L.; McClure, J. M.; Smith, J. S.*; Brenner, C. B.* Cell 2007, 129, 473-484.
[ Abstract ]

7 May 2007, presented by Xuequan Lu
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Siddiquee, K.; Zhang, S.; Guida, W. C.; Blaskovich, M. A.; Greedy, B.; Lawrence, H. R.; Yip, M. L. R.; Jove, R.; McLaughlin, M. M.; Lawrence, N. J.; Sebti, S. M.; Turkson, J.* Proc. Natl. Acad. Sci. USA 2007, 104, 7391-7396.
[ Abstract ]

2 May 2007, presented by Chris DiBlasi
Chemical genetics reveals a complex functional ground state of neural stem cells.
Diamandis, P.; Wildenhain, J.; Clarke, I. D.; Sacher, A. G.; Graham, J.; Bellows, D. S.; Ling, E. K. M.; Ward, R. J.; Jamieson, L. G., Tyers, M.*; Dirks, P. B.* Nat. Chem. Biol. 2007, 3, 268-273.
[ Abstract ]

23 Apr 2007, presented by Guodong Liu
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Venkatraman, P.; Nguyen, T. T.; Sainlos, M.; Bilsel, O.; Chitta, S.; Imperiali, B.*; Stern, L. J.* Nat. Chem. Biol. 2007, 3, 222-228.
[ Abstract ]

9 Apr 2007, presented by Justin Cisar
A streamlined metabolic pathway for the biosynthesis of moenomycin A.
Ostash, B.; Saghatelian, A.; Walker, S.* Chem. Biol. 2007, 14, 257-267.
[ Abstract ]

2 Apr 2007, presented by Shiying Shang
The site-specific installation of methyl-lysine analogs into recombinant histones.
Simon, M. D.; Chu, F.; Racki, L. R.; de la Cruz, C. C.; Burlingame, A. L.; Panning, B.; Narlikar, G. J.; Shokat, K. M.* Cell 2007, 128, 1003-1012.
[ Abstract ]

20 Mar 2007, presented by Sirkka Moilanen
Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.
Janowski, B. A.*; Younger, S. T.; Hardy, D. B.; Ram, R.; Huffman, K. E.; Corey, D. R.* Nat. Chem. Biol. 2007, 3, 166-173.
[ Abstract ]

5 Mar 2007, presented by Xuequan Lu
Noxious compounds activate TRPA1 ion channels through covalent modifcation of cysteines.
Macpherson, L. J.; Dubin, A. E.; Evans, M. J.; Marr, F.; Schultz, P. G.; Cravatt, B. F.; Patapoutian, A.* Nature 2007, 445, 541-545.
[ Abstract ]

27 Feb 2007, presented by Christine DiBlasi
Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.
Hsu, T.-L.; Hanson, S. R.; Kishikawa, K.; Wang, S.-K.; Sawa, M.; Wong, C.-H.* Proc. Natl. Acad. Sci. USA 2007, 104, 2614-2619.
[ Abstract ]

19 Feb 2007, presented by Guodong Liu
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.
Kawaguchi, R.; Yu, J.; Honda, J.; Hu, J.; Whitelegge, J.; Ping, P.; Wiita, P.; Bok, D.; Sun, H.* Science 2007, 315, 820-825.
[ Abstract ]

12 Feb 2007, presented by Justin Cisar
Pyocyanin isolated from a marine microbial population: Synergistic production between two distinct bacterial species and mode of action.
Angell, S.; Bench, B. J.; Williams, H.; Watanabe, C. M. H.* Chem. Biol. 2006, 13, 1349-1359.
[ Abstract ]

29 Jan 2007, presented by Shiying Shang
Activity-based probes for proteomic profiling of histone deacetylase complexes.
Salisbury, C. M.; Cravatt, B. F.* Proc. Natl. Acad. Sci. USA 2007, 104, 1171-1176.
[ Abstract ]

22 Jan 2007, presented by Sirkka Moilanen
Small-molecule mimics of an α-helix for efficient transport of proteins into cells.
Okuyama, M.; Laman, H.; Kingsbury, S. R; Visintin, C.; Leo, E.; Leigh Eward, K.; Stoeber, K.; Boshoff, C.; Williams, G. H.; Selwood D. L.* Nat. Methods 2007, 4, 153-159.
[ Abstract ]

15 Jan 2007, presented by Xuequan Lu
Engineering yeast transcription machinery for improved ethanol tolerance and production.
Alper, H.; Moxley, J.; Nevoigt, E; Fink G. R.; Stephanopoulos, G* Science 2005, 314, 1565-1568.
[ Abstract ]

8 Jan 2007, presented by Hayato Iwadare
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.
Min, J.; Kim, Y. K.; Cipriani, P. G.; Kang, M.; Khersonsky, S. M.; Walsh, D. P.; Lee, J.-Y.; Niessen, S.; Yates, J. R.; Gunsalus, K.; Piano, F.; Chang, Y.-T.* Nat. Chem. Biol. 2007, 3, 55-59.
[ Abstract ]